| Processo: | 12/50722-0 |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Data de Início da vigência: | 01 de outubro de 2012 |
| Data de Término da vigência: | 30 de setembro de 2014 |
| Área do conhecimento: | Ciências da Saúde - Medicina - Radiologia Médica |
| Acordo de Cooperação: | King's College London |
| Pesquisador responsável: | Edson Amaro Junior |
| Beneficiário: | Edson Amaro Junior |
| Pesquisador Responsável no exterior: | Thomas White |
| Instituição Parceira no exterior: | King's College London , Inglaterra |
| Instituição Sede: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brasil |
| Município da Instituição Sede: | São Paulo |
| Vinculado ao auxílio: | 09/53443-1 - Neuroimunologia, genômica funcional e neuroimagem: uma abordagem integrada no estudo da fisiopatologia e tratamento da epilepsia refratária, AP.TEM |
| Assunto(s): | Imagem por ressonância magnética funcional Técnicas de diagnóstico neurológico Esquizofrenia Anfetamina |
| Palavra(s)-Chave do Pesquisador: | Amphetamine | Cortical Efficiency | Eeg Fmri | Fmri | Neural Processing Time | Schizophrenia |
Resumo
Morphometric features of the hemodynamic response function (HRF) potentially provide a window on to alternative characteristics of neuronal activity using fMRI. Recently, neural processing time (NPT) - the period for which event-related neuonal activity occurs - was proposed as a measurable feature of the biophysical model of HRF. However, systematic investigation of the factors modulating NPT has not yet been conducted but could potentially mark a significant improvement of our understanding of the neural conditions characteristic of efficient information processing. Accordingly, we propose a collaborative study which will adapt NPT inference, developed at USP, to test four principal hypotheses on N-back data previously collected at KCL: (i) that NPT in decision-making regions will be modulated by working memory load, being shorter in low memory-load conditions; (ii) that individuals with psychosis will exhibit aberrant NPT on account of diminished cortical efficiency, with psychosis-related differences moderated by symptom profile; (iii) that this aberrance will be mirrored by healthy individuals following amphetamine sensitisation; and (iv) that simultaneously acquired electroencephalography (EEG)-fMRI data collected during working memory performance will provide a means of further validating NPT by permitting the assessment of the relationship between neuroelectric components (from EEG) and fMRI NPT measures. (AU)
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