Low frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sample

Autor(es):Mostrar menos -

Hoexter, Marcelo Q. ^{[1, 2, 3]} ; Biazoli, Jr., Claudinei E. ^[4] ; Alvarenga, Pedro G. ^{[1, 3]} ; Batistuzzo, Marcelo C. ^{[1, 3]} ; Salum, Giovanni A. ^{[5, 1]} ; Gadelha, Ary ^{[1, 2]} ; Pan, Pedro M. ^{[1, 2]} ; Anes, Mauricio ^{[5, 1, 6]} ; Mancini-Martins, Leticia ^[4] ; Moura, Luciana M. ^{[1, 4]} ; Soriano-Mas, Caries ^{[7, 8, 9]} ; Aquilla, Marco A. G. Del' ^{[1, 2]} ; Arnaro, Jr., Edson ^[10] ; Rohde, Luis A. ^{[5, 1]} ; Jackowski, Andrea P. ^{[1, 2]} ; Bressan, Rodrigo A. ^{[1, 2]} ; Miguel, Euripedes C. ^{[1, 3]} ; do Rosario, Maria C. ^{[1, 11]} ; Sato, Joao R. ^{[1, 4]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept & Inst Psiquiatria, Fac Med FMUSP, Sao Paulo, SP - Brazil

^[4] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre - Brazil

^[5] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil

^[6] Hosp Clin Porto Alegre, Med Phys & Radioprotect Serv, Porto Alegre, RS - Brazil

^[7] Carlos III Hlth Inst, Dept Psychiat, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Barcelona - Spain

^[8] Carlos III Hlth Inst, CIBERSAM, Barcelona - Spain

^[9] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona - Spain

^[10] Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo - Brazil

^[11] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PSYCHIATRIC RESEARCH; v. 96, p. 224-230, JAN 2018.
• Citações Web of Science: 1

Resumo

Background: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. Method: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian `High Risk Cohort Study for Psychiatric Disorders (HRC)'. OCS were assessed using items from the Compulsion and Obsessions section of the Development and Well-Being Assessment (DAWBA). The correlation between the fractional amplitude of low frequency fluctuations (fALFF) and the number of OCS were explored by using a general linear model, considering fALFF as response variable, OCS score as regressor and age, gender and site as nuisance variables. Results: The number of OCS was positively correlated with the fALFF coefficients at the right sensorimotor cortex (pre-motor, primary motor cortex and post-central gyrus) and negatively correlated with the fALFF coefficients at the insula/superior temporal gyrus of both hemispheres. Our results were specific to OCS and not due to associations with overall psychopathology. Conclusions: Our results suggest that brain spontaneous activity at rest in the sensorimotor and insular/superior-temporal cortices may be involved in OCS in children. These findings need independent replication and future studies should determine whether brain spontaneous activity changes within these regions might be predictors of risk for obsessive-compulsive disorder latter in life. (AU)

• Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
• Beneficiário: Andrea Parolin Jackowski
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/57896-8 - O Instituto Nacional da Psiquiatria do Desenvolvimento: uma nova abordagem para a psiquiatria tendo como foco as nossas crianças e o seu futuro
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/00506-1 - Séries temporais, ondaletas e análise de dados funcionais
• Beneficiário: Pedro Alberto Morettin
• Modalidade de apoio: Auxílio à Pesquisa - Temático
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• Beneficiário: Marcelo Camargo Batistuzzo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
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• Beneficiário: Rodrigo Affonseca Bressan
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 12/50722-0 - Factors modulating neural processing time measured using fMRI
• Beneficiário: Edson Amaro Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Beneficiário: João Ricardo Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular