Low frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sample

Author(s):Show less -

Hoexter, Marcelo Q. ^{[1, 2, 3]} ; Biazoli, Jr., Claudinei E. ^[4] ; Alvarenga, Pedro G. ^{[1, 3]} ; Batistuzzo, Marcelo C. ^{[1, 3]} ; Salum, Giovanni A. ^{[5, 1]} ; Gadelha, Ary ^{[1, 2]} ; Pan, Pedro M. ^{[1, 2]} ; Anes, Mauricio ^{[5, 1, 6]} ; Mancini-Martins, Leticia ^[4] ; Moura, Luciana M. ^{[1, 4]} ; Soriano-Mas, Caries ^{[7, 8, 9]} ; Aquilla, Marco A. G. Del' ^{[1, 2]} ; Arnaro, Jr., Edson ^[10] ; Rohde, Luis A. ^{[5, 1]} ; Jackowski, Andrea P. ^{[1, 2]} ; Bressan, Rodrigo A. ^{[1, 2]} ; Miguel, Euripedes C. ^{[1, 3]} ; do Rosario, Maria C. ^{[1, 11]} ; Sato, Joao R. ^{[1, 4]}

Affiliation:Show less -

^[1] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept & Inst Psiquiatria, Fac Med FMUSP, Sao Paulo, SP - Brazil

^[4] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre - Brazil

^[5] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil

^[6] Hosp Clin Porto Alegre, Med Phys & Radioprotect Serv, Porto Alegre, RS - Brazil

^[7] Carlos III Hlth Inst, Dept Psychiat, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Barcelona - Spain

^[8] Carlos III Hlth Inst, CIBERSAM, Barcelona - Spain

^[9] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona - Spain

^[10] Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo - Brazil

^[11] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF PSYCHIATRIC RESEARCH; v. 96, p. 224-230, JAN 2018.
• Web of Science Citations: 1

Abstract

Background: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. Method: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian `High Risk Cohort Study for Psychiatric Disorders (HRC)'. OCS were assessed using items from the Compulsion and Obsessions section of the Development and Well-Being Assessment (DAWBA). The correlation between the fractional amplitude of low frequency fluctuations (fALFF) and the number of OCS were explored by using a general linear model, considering fALFF as response variable, OCS score as regressor and age, gender and site as nuisance variables. Results: The number of OCS was positively correlated with the fALFF coefficients at the right sensorimotor cortex (pre-motor, primary motor cortex and post-central gyrus) and negatively correlated with the fALFF coefficients at the insula/superior temporal gyrus of both hemispheres. Our results were specific to OCS and not due to associations with overall psychopathology. Conclusions: Our results suggest that brain spontaneous activity at rest in the sensorimotor and insular/superior-temporal cortices may be involved in OCS in children. These findings need independent replication and future studies should determine whether brain spontaneous activity changes within these regions might be predictors of risk for obsessive-compulsive disorder latter in life. (AU)

• FAPESP's process: 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study
• Grantee: Andrea Parolin Jackowski
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/57896-8 - National Institute for Developmental Psychiatry
• Grantee: Eurípedes Constantino Miguel Filho
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/00506-1 - Time series, wavelets and functional data analysis
• Grantee: Pedro Alberto Morettin
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/05865-8 - Ventromedial prefrontal cortex metabolite levels in obsessive-compulsive patients: a proton magnetic resonance spectroscopy study
• Grantee: Marcelo Camargo Batistuzzo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/02246-5 - Investigation of the brain connectivity patterns associated with psychotic experiences throughout infancy and adolescence and the genetic and environmental modulation
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 12/50722-0 - Factors modulating neural processing time measured using fMRI
• Grantee: Edson Amaro Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
• Grantee: João Ricardo Sato
• Support Opportunities: Regular Research Grants