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Predictor factors for metabolic diseases in obsessive-compulsive disorder patients

Grant number: 13/24652-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2014
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Eurípedes Constantino Miguel Filho
Grantee:Eduardo Ferracioli Oda
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/21357-9 - Research on neural circuits and biological markers involved in obsessive-compulsive disorder using behavioral paradigms of fear and anxiety, AP.TEM

Abstract

The obsessive-compulsive disorder (OCD) is a heterogeneous disorder with multiple symptoms, ages at onset and treatment responses. This heterogeneity interferes in its ethiology research. Several theories have been set for the origin of OCD. For instance, it is believed that OCD arises from the interaction between genetic and enviromental factors, that in turn changes the normal developmental process, also leading to structural and functional changes in specific brain circuits. Those changes have impact on the concentration and function of neurotransmitters and, as more recently beleived, on the imune system functioning. Changes in inflammatory mediators (i.e. pro and anti-inflammatory cytokines) were observed in patients with depression, schizophrenia and, on an inconclusive way, on OCD.Inflammatory mediators alterations have been also noticed in metabolic diseases, whose incidences increase on the presence of metabolic syndrome. One study evaluated the prevalence of that syndrome in patients with OCD, showing that metabolic syndrome was present between 17.2% to 21.2% of the patients with OCD.In this way, it is intended to evaluate the prevalence of obesity and diabetes mellitus in patients with OCD who participated in the Brazilian Consortium of Research of Obsessive-Compulsive Spectrum Disorders (C-TOC) in the period of 2003 to 2009, as well evaluate its association with early factors of metabolic diseases, as low birth weight.