Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders

• Grant number: 13/10498-6
• Support Opportunities: Regular Research Grants
• Duration: October 01, 2013 - September 30, 2015
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: João Ricardo Sato
• Grantee: João Ricardo Sato
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated researchers: Andrea Parolin Jackowski ; Carlos Eduardo Thomaz ; Marcelo Queiroz Hoexter ; Rodrigo Affonseca Bressan

Abstract

Neuroimaging methods technology such as functional MRI, tractography, voxel-based morphometry, analysis of cortical surface are advancing rapidly, allowing the observation of distinct aspects of brain structure and function, playing a fundamental contribution to the understanding of mental disorders (MD). Traditionally, "average" comparison between groups of healthy subjects and patients with MD has contributed to the enhance the comprehension of the ethiology and neural substrates of pathologies. Since the changes are subtle and variability of the data is large, there is an overlap between the two groups. This overlap strongly constrains the use of neuroimaging techniques in clinical practice, since they can not be applied to single individual diagnosis. Thus, a major challenge in psychiatry is the discovery of biomarkers such as neuroimaging, which are useful both for diagnosis of TM and to predict the efficacy of treatments with drugs and / or therapies (prognosis). Subtle brain changes are spatially distributed and difficult to detect with the naked eye but can be detected with the use of machine learning methods. In previous work of our group, we could demonstrate that some of these techniques allow to obtain predictions of mental states (e.g., pathological or refractory) to the individual case. In this project, we want to make a conceptual jump in development of methods and applications in psychiatry. This jump underlies on the use of large neuroimaging non-public databases (on the order of hundreds of individuals) to be combined with genetic (DNA and RNA) to validate the techniques previously developed and perform data mining to discover markers for psychiatric disorders. We hope to find potential biomarkers for schizophrenia through measures of connectivity and genetic polymorphisms. Furthermore, we study trajectories of functional connectivity to identify potential early markers of risk for MD in a sample (unprecedented in the world) including more than 750 children with healthy development and children at high risk for TM. Our group has been successful in developing methodologies combining advanced methods of pattern recognition neuroimaging to MD. This project is in accordance of current literature which reinforces the relevance of technological advances for diagnostics and prognosis in psychiatry. (AU)

Scientific publications

(40)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BALARDIN, JOANA BISOL; SATO, JOAO RICARDO; VIEIRA, GILSON; FENG, YEU; DALY, EILEEN; MURPHY, CLODAGH; MURPHY, DECLAN; ECKER, CHRISTINE; CONSORTIUM, MRC AIMS. Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay. Autism Research, v. 8, n. 5, p. 556-566, OCT 2015. (09/09924-5, 13/10498-6)

MOLL, JORGE; WEINGARTNER, JULIE H.; BADO, PATRICIA; BASILIO, RODRIGO; SATO, JOAO R.; MELO, BRUNO R.; BRAMATI, IVANEI E.; DE OLIVEIRA-SOUZA, RICARDO; ZAHN, ROLAND. Voluntary Enhancement of Neural Signatures of Affiliative Emotion Using fMRI Neurofeedback. PLoS One, v. 9, n. 5, MAY 21 2014. (13/10498-6)

ANDRÉ ZUGMAN; JOÃO R. SATO; ANDREA P. JACKOWSKI. Crisis in neuroimaging: is neuroimaging failing 15 years after the decade of the brain?. Revista Brasileira de Psiquiatria, v. 38, n. 4, p. 267-269, 2016-12-00. (13/08531-5, 13/00506-1, 13/10498-6)

OTA, VANESSA KIYOMI; NOTO, CRISTIANO; GADELHA, ARY; SANTORO, MARCOS LEITE; ORTIZ, BRUNO BERTOLUCCI; ANDRADE, ELVIS HENRIQUE; TASSO, BRAZILIO CARVALHO; NERY SPINDOLA, LETICIA MARIA; SILVA, PATRICIA NATALIA; ABILIO, VANESSA COSTHEK; et al. Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naive patients with first-episode psychosis. JOURNAL OF PSYCHIATRIC RESEARCH, v. 56, p. 130-136, SEP 2014. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

TRAMBAIOLLI, L. R.; SPOLAOR, N.; LORENA, A. C.; ANGHINAH, R.; SATO, J. R.. Feature selection before EEG classification supports the diagnosis of Alzheimer's disease. CLINICAL NEUROPHYSIOLOGY, v. 128, n. 10, p. 2058-2067, OCT 2017. (12/22608-8, 13/00506-1, 13/10952-9, 13/10498-6)

SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation. DEVELOPMENTAL COGNITIVE NEUROSCIENCE, v. 20, p. 2-11, AUG 2016. (13/00506-1, 13/08531-5, 13/10498-6, 08/57896-8)

SUBIRA, MARTA; CANO, MARTA; DE WIT, STELLA J.; ALONSO, PINO; CARDONER, NARCIS; HOEXTER, MARCELO Q.; KWON, JUN SOO; NAKAMAE, TAKASHI; LOCHNER, CHRISTINE; SATO, JOAO R.; et al. Structural covariance of neostriatal and limbic regions in patients with obsessive-compulsive disorder. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, v. 41, n. 2, p. 115-123, MAR 2016. (13/10498-6)

SATO, JOAO RICARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; VIEIRA, GILSON; ZUGMAN, ANDRE; HOEXTER, MARCELO QUEIROI; ANES, MAURICIO; MOURA, LUCIANA MONTEIRO; et al. Age effects on the default mode and control networks in typically developing children. JOURNAL OF PSYCHIATRIC RESEARCH, v. 58, p. 89-95, NOV 2014. (13/00506-1, 13/10498-6)

GOUVEA, E. S.; OTA, V. K.; NOTO, C.; SANTORO, M. L.; SPINDOLA, L. M.; MORETTI, P. N.; CARVALHO, C. M.; XAVIER, G.; RIOS, A. C.; SATO, J. R.; et al. Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis. TRANSLATIONAL PSYCHIATRY, v. 6, OCT 4 2016. (11/50740-5, 14/50830-2, 12/12686-1, 13/10498-6, 10/08968-6, 14/07280-1)

SIQUEIRA, ANDERSON DOS SANTOS; BIAZOLI JUNIOR, CLAUDINEI EDUARDO; COMFORT, WILLIAM EDGAR; ROHDE, LUIS AUGUSTO; SATO, JOAO RICARDO. Abnormal Functional Resting-State Networks in ADHD: Graph Theory and Pattern Recognition Analysis of fMRI Data. BIOMED RESEARCH INTERNATIONAL, 2014. (13/00506-1, 12/13390-9, 13/10498-6)

OTA, VANESSA KIYOMI; NOTO, CRISTIANO; GADELHA, ARY; SANTORO, MARCOS LEITE; SPINDOLA, LETICIA MARIA; GOUVEA, EDUARDO SAUERBRONN; STILHANO, ROBERTA SESSA; ORTIZ, BRUNO BERTOLUCCI; SILVA, PATRICIA NATALIA; SATO, JOAO RICARDO; et al. Changes in gene expression and methylation in the blood of patients with first-episode psychosis. SCHIZOPHRENIA RESEARCH, v. 159, n. 2-3, p. 358-364, NOV 2014. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

SATO, JOAO RICARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; ANES, MAURICIO; MOURA, LUCIANA MONTEIRO; et al. Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study. NeuroImage, v. 104, p. 44-51, JAN 1 2014. (13/00506-1, 13/10498-6, 08/57896-8)

GIMENEZ, MONICA; GUINEA-IZQUIERDO, ANDRES; VILLALTA-GIL, VICTORIA; MARTINEZ-ZALACAIN, IGNACIO; SEGALAS, CINTO; SUBIRA, MARTA; REAL, EVA; PUJOL, JESUS; HARRISON, BEN J.; MARIA HARO, JOSEP; et al. Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder. BRAIN IMAGING AND BEHAVIOR, v. 11, n. 6, p. 1690-1706, DEC 2017. (13/10498-6)

VIDAL, MACIEL C.; SATO, JOAO R.; BALARDIN, JOANA B.; TAKAHASHI, DANIEL Y.; FUJITA, ANDRE. ANOCVA in R: A Software to Compare Clusters between Groups and Its Application to the Study of Autism Spectrum Disorder. FRONTIERS IN NEUROSCIENCE, v. 11, JAN 24 2017. (16/13422-9, 13/03447-6, 15/01587-0, 13/10498-6, 14/09576-5)

TRAMBAIOLLI, LUCAS R.; BIAZOLI, JR., CLAUDINEI E.; BALARDIN, JOANA B.; HOEXTER, MARCELO Q.; SATO, JOAO R.. The relevance of feature selection methods to the classification of obsessive compulsive disorder based on volumetric measures. Journal of Affective Disorders, v. 222, p. 49-56, NOV 2017. (15/17406-5, 13/10498-6, 11/21357-9)

ROCHA, THIAGO BOTTER-MAIO; HUTZ, MARA H.; SALATINO-OLIVEIRA, ANGELICA; GENRO, JULIA P.; POLANCZYK, GUILHERME V.; SATO, JOAO RICARDO; WEHRMEISTER, FERNANDO C.; BARROS, FERNANDO C.; MENEZES, ANA M. B.; ROHDE, LUIS AUGUSTO; et al. Gene-Environment Interaction in Youth Depression: Replication of the 5-HTTLPR Moderation in a Diverse Setting. American Journal of Psychiatry, v. 172, n. 10, p. 978-985, OCT 2015. (13/00506-1, 13/10498-6)

BALARDIN, JOANA BISOL; COMFORT, WILLIAM EDGAR; DALY, EILEEN; MURPHY, CLODAGH; ANDREWS, DEREK; MURPHY, DECLAN G. M.; ECKER, CHRISTINE; SATO, JOAO RICARDO; CONSORTIUM, MRC AIMS. Decreased centrality of cortical volume covariance networks in autism spectrum disorders. JOURNAL OF PSYCHIATRIC RESEARCH, v. 69, p. 142-149, OCT 2015. (13/10498-6)

NOTO, CRISTIANO; OTA, VANESSA KIYOMI; SANTORO, MARCOS LEITE; GOUVEA, EDUARDO SAUERBRONN; SILVA, PATRICIA NATALIA; SPINDOLA, LETICIA MARIA; CORDEIRO, QUIRINO; BRESSAN, RODRIGO AFFONSECA; GADELHA, ARY; BRIETZKE, ELISA; et al. Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naive First Episode Psychosis. Molecular Neurobiology, v. 53, n. 8, p. 5701-5709, OCT 2016. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

PINAYA, WALTER H. L.; GADELHA, ARY; DOYLE, ORLA M.; NOTO, CRISTIANO; ZUGMAN, ANDRE; CORDEIRO, QUIRINO; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; SATO, JOAO R.. Using deep belief network modelling to characterize differences in brain morphometry in schizophrenia. SCIENTIFIC REPORTS, v. 6, DEC 12 2016. (13/05168-7, 13/10498-6)

BIAZOLI JR, CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; REBELLO, KEILA; MOURA, LUCIANA MONTEIRO; PAN, PEDRO MARIO; BRIETZKE, ELISA; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; BRESSAN, RODRIGO AFFONSECA; et al. Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus. BRAIN IMAGING AND BEHAVIOR, v. 14, n. 4, p. 961-970, AUG 2020. (13/00506-1, 13/08531-5, 13/10498-6, 08/57896-8)

SATO, JOAO RICARDO; BIAZOLI JR, CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 28, n. 6, p. 835-845, JUN 2019. (13/10498-6, 13/08531-5, 13/00506-1)

DE MOURA, ADRIANA MIYAZAKI; LOPEZ PINAYA, WALTER HUGO; GADELHA, ARY; ZUGMAN, ANDRE; NOTO, CRISTIANO; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; SATO, JOAO RICARDO. Investigating brain structural patterns in first episode psychosis and schizophrenia using MRI and a machine learning approach. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 275, p. 14-20, MAY 30 2018. (13/10498-6, 13/08531-5, 14/07280-1, 13/05168-7)

PINAYA, WALTER H. L.; MECHELLI, ANDREA; SATO, JOAO R.. Using deep autoencoders to identify abnormal brain structural patterns in neuropsychiatric disorders: A large-scale multi-sample study. Human Brain Mapping, v. 40, n. 3, p. 944-954, FEB 15 2019. (13/10498-6)

SATO, JOAO RICARDO; VIDAL, MACIEL CALEBE; SANTOS, SUZANA DE SIQUEIRA; MASSIRER, KATLIN BRAUER; FUJITA, ANDRE. Complex Network Measures in Autism Spectrum Disorders. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, v. 15, n. 2, p. 581-587, MAR-APR 2018. (12/00195-3, 13/00506-1, 13/03447-6, 14/09576-5, 13/10498-6)

FUJITA, ANDRE; TAKAHASHI, DANIEL YASUMASA; BALARDIN, JOANA BISOL; VIDAL, MACIEL CALEBE; SATO, JOAO RICARDO. Correlation between graphs with an application to brain network analysis. COMPUTATIONAL STATISTICS & DATA ANALYSIS, v. 109, p. 76-92, MAY 2017. (13/10498-6, 16/13422-9, 13/00506-1, 15/01587-0)

SATO, JOAO RICARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; MANFRO, GISELE GUS; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Default mode network maturation and psychopathology in children and adolescents. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. 57, n. 1, p. 55-64, JAN 2016. (13/00506-1, 13/08531-5, 13/10498-6)

HOEXTER, MARCELO Q.; DINIZ, JULIANA B.; LOPES, ANTONIO C.; BATISTUZZO, MARCELO C.; SHAVITT, ROSELI G.; DOUGHERTY, DARIN D.; DURAN, FABIO L. S.; BRESSAN, RODRIGO A.; BUSATTO, GERALDO F.; MIGUEL, EURIPIDES C.; et al. ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE-COMPULSIVE DISORDER. DEPRESSION AND ANXIETY, v. 32, n. 12, p. 900-908, DEC 2015. (13/00506-1, 13/10498-6, 11/21357-9)

ZUGMAN, ANDRE; ASSUNCAO, IDAIANE; VIEIRA, GILSON; GADELHA, ARY; WHITE, THOMAS P.; OLIVEIRA, PEDRO PAULO M.; NOTO, CRISTIANO; CROSSLEY, NICOLAS; MCGUIRE, PHILIP; CORDEIRO, QUIRINO; et al. Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis. JOURNAL OF PSYCHIATRIC RESEARCH, v. 71, p. 89-96, DEC 2015. (13/00506-1, 13/10498-6, 11/50740-5)

SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; SATTERTHWAITE, THEODORE D.; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; et al. Temporal Stability of Network Centrality in Control and Default Mode Networks: Specific Associations with Externalizing Psychopathology in Children and Adolescents. Human Brain Mapping, v. 36, n. 12, p. 4926-4937, DEC 2015. (13/00506-1, 13/10498-6, 08/57896-8)

NOTO, CRISTIANO; OTA, VANESSA KIYOMI; SANTORO, MARCOS LEITE; ORTIZ, BRUNO B.; RIZZO, LUCAS B.; HIGUCHI, CINTHIA HIROKO; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; BRESSAN, RODRIGO AFFONSECA; GADELHA, ARY; et al. Effects of depression on the cytokine profile in drug naive first-episode psychosis. SCHIZOPHRENIA RESEARCH, v. 164, n. 1-3, p. 53-58, MAY 2015. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

SATO, JOAO R.; BASILIO, RODRIGO; PAIVA, FERNANDO F.; GARRIDO, GRISELDA J.; BRAMATI, IVANEI E.; BADO, PATRICIA; TOVAR-MOLL, FERNANDA; ZAHN, ROLAND; MOLL, JORGE. Real-Time fMRI Pattern Decoding and Neurofeedback Using FRIEND: An FSL-Integrated BCI Toolbox. PLoS One, v. 8, n. 12, DEC 2 2013. (13/10498-6)

SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 19, n. 2, p. 119-129, 2018. (13/08531-5, 08/57896-8, 13/10498-6, 13/00506-1)

DE MOURA, LUCIANA MONTEIRO; COGO-MOREIRA, HUGO; BRANDAO DE AVILA, CLARA REGINA; PAN, PEDRO MARIO; GADELHA, ARY; MORIYAMA, TAIS; DEL AQUILLA, MARCO ANTONIO; HOEXTER, MARCELO; SALUM, GIOVANNI ABRAHAO; PICON, FELIPE ALMEIDA; et al. Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres. BRAIN CONNECTIVITY, v. 6, n. 7, p. 519-523, SEP 2016. (13/10498-6)

NOTO, CRISTIANO; OTA, VANESSA KIYOMI; GADELHA, ARY; NOTO, MARIANE NUNES; BARBOSA, DECIO SABBATINI; BONIFACIO, KAMILA LANDUCCI; NUNES, SANDRA ODEBRECHT; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; BRESSAN, RODRIGO AFFONSECA; et al. Oxidative stress in drug naive first episode psychosis and antioxidant effects of risperidone. JOURNAL OF PSYCHIATRIC RESEARCH, v. 68, p. 210-216, SEP 2015. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

SUBIRA, MARTA; SATO, JOAO R.; ALONSO, PINO; DO ROSARIO, MARIA C.; SEGALAS, CINTO; BATISTUZZO, MARCELO C.; REAL, EVA; LOPES, ANTONIO C.; CERRILLO, ESTER; DINIZ, JULIANA B.; et al. Brain structural correlates of sensory phenomena in patients with obsessive-compulsive disorder. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, v. 40, n. 4, p. 232-240, JUL 2015. (11/21357-9, 13/00506-1, 11/00968-0, 13/22536-0, 13/10498-6)

MOURA, L. M.; CROSSLEY, N. A.; ZUGMAN, A.; PAN, P. M.; GADELHA, A.; DEL AQUILLA, M. A. G.; PICON, F. A.; ANES, M.; AMARO, JR., E.; DE JESUS MARI, J.; et al. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. BRAIN IMAGING AND BEHAVIOR, v. 11, n. 3, p. 808-817, JUN 2017. (13/00506-1, 13/08531-5, 13/10498-6, 08/57896-8)

MOURA, LUCIANA MONTEIRO; KEMPTON, MATTHEW; BARKER, GARETH; SALUM, GIOVANNI; GADELHA, ARY; PAN, PEDRO MARIO; HOEXTER, MARCELO; GOMES DEL AQUILLA, MARCO ANTONIO; PICON, FELIPE ALMEIDA; ANES, MAURICIO; et al. Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence. MAGNETIC RESONANCE IMAGING, v. 34, n. 4, p. 529-534, MAY 2016. (13/00506-1, 13/08531-5, 13/10498-6)

DE OLIVEIRA, AILTON ANDRADE; CARTHERY-GOULART, MARIA TERESA; DE MAGALHAES OLIVEIRA JUNIOR, PEDRO PAULO; CARRETTIERO, DANIEL CARNEIRO; SATO, JOAO RICARDO; INITI, ALZHEIMER'S DIS NEUROIMAGING. Defining Multivariate Normative Rules for Healthy Aging using Neuroimaging and Machine Learning: An Application to Alzheimer's Disease. JOURNAL OF ALZHEIMER'S DISEASE, v. 43, n. 1, p. 201-212, 2015. (13/00506-1, 13/10498-6)

FUJITA, ANDRE; TAKAHASHI, DANIEL Y.; PATRIOTA, ALEXANDRE G.; SATO, JOAO R.. A non-parametric statistical test to compare clusters with applications in functional magnetic resonance imaging data. STATISTICS IN MEDICINE, v. 33, n. 28, p. 4949-4962, DEC 10 2014. (12/21788-2, 11/50761-2, 14/09576-5, 13/10498-6)

HOEXTER, MARCELO Q.; BIAZOLI, JR., CLAUDINEI E.; ALVARENGA, PEDRO G.; BATISTUZZO, MARCELO C.; SALUM, GIOVANNI A.; GADELHA, ARY; PAN, PEDRO M.; ANES, MAURICIO; MANCINI-MARTINS, LETICIA; MOURA, LUCIANA M.; et al. Low frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sample. JOURNAL OF PSYCHIATRIC RESEARCH, v. 96, p. 224-230, JAN 2018. (13/08531-5, 08/57896-8, 13/00506-1, 16/05865-8, 16/02246-5, 12/50722-0, 13/10498-6)