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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

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Moura, Luciana Monteiro [1, 2, 3] ; Kempton, Matthew [3] ; Barker, Gareth [3] ; Salum, Giovanni [4, 5] ; Gadelha, Ary [1, 2] ; Pan, Pedro Mario [1, 2] ; Hoexter, Marcelo [6] ; Gomes Del Aquilla, Marco Antonio [1, 2] ; Picon, Felipe Almeida [4, 5] ; Anes, Mauricio [4] ; Garcia Otaduy, Maria Concepcion [6] ; Amaro, Jr., Edson [6] ; Rohde, Luis Augusto [4, 5] ; McGuire, Philip [3] ; Bressan, Rodrigo Affonseca [1, 2] ; Sato, Joao Ricardo [7] ; Jackowski, Andrea Parolin [1, 2]
Total Authors: 17
[1] Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570, 1 Andar, BR-04039032 Sao Paulo - Brazil
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS - England
[4] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil
[5] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, BR-90046900 Porto Alegre, RS - Brazil
[6] Univ Sao Paulo, Lab Magnet Resonance Neuroradiol, LIM 44, Inst & Dept Radiol, Sao Paulo - Brazil
[7] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil
Total Affiliations: 7
Document type: Journal article
Source: MAGNETIC RESONANCE IMAGING; v. 34, n. 4, p. 529-534, MAY 2016.
Web of Science Citations: 10

In the last decade, several studies have described the typical brain white matter maturation in children and adolescents. Diffusion tensor imaging (DTI) is the most frequent MRI technique used to investigate the structural changes across development. However, few previous studies have used the magnetization transfer ratio (MTR), which gives a closer measure of myelin content. Here, we employed both techniques for the same sample of 176 typically developing children from 7 to 14 years of age. We investigated the associations between DTI parameters and MTR measure, to assess the myelination in the brain in development. Secondly, we investigated age-effects on DTI parameters (fractional anisotropy, axial, radial and mean diffusivities) and MTR. No significant correlations between MTR and DTI parameters were observed. In addition, a significant age-effect was detected for DTI data but was not visible for MTR data. Thereby, changes in white matter at this age might be primarily correlated with microstructural changes. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
Grantee:João Ricardo Sato
Support type: Regular Research Grants
FAPESP's process: 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study
Grantee:Andrea Parolin Jackowski
Support type: Regular Research Grants
FAPESP's process: 13/00506-1 - Time series, wavelets and functional data analysis
Grantee:Pedro Alberto Morettin
Support type: Research Projects - Thematic Grants