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White matter integrity of the corpus callosum and neuropsychological performance in maltreated children and adolescents: a brain morphometric and diffusion tensor imaging study

Grant number: 10/15786-1
Support type:Regular Research Grants
Duration: February 01, 2011 - January 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Geraldo Busatto Filho
Grantee:Geraldo Busatto Filho
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Alvaro Machado Dias ; Paula Approbato de Oliveira ; Paulo Jannuzzi Cunha ; Sandra Scivoletto ; Tiffany Moukbel Chaim

Abstract

Despite the high prevalence of children and adolescent maltreatment (CAM), research studies evaluating the effects of maltreatment on brain anatomy and neuropsychological functioning in this population are still limited. There is evidence of reduced volume of the corpus callosum (CC) in association with CAM, but no study to date has evaluated the association between abnormalities of white matter (WM) tracts in the CC, interhemispheric transfer of information, and decision making, taking into account the period when the maltreatment has began. The aim of this study is to investigate the relationship between integrity, size and deformity of the CC, interhemispheric transfer of somatosensory information, and decision making in maltreated children and adolescents. The sample consists of 100 children and adolescents, between 8-17 years old, divided in 60 maltreated and 40 control individuals. They will undergo brain magnetic resonance imaging (MRI) scanning; white matter integrity, regional volumes, and surface patterns of the CC will be determined by methods combining Diffusion Tensor Imaging (DTI), Voxel-Based Morphometry (VBM), and Surface-Based Modeling (SBM), respectively. Neuropsychological assessment will consist of the Crossed Finger Localization Test (CFLT), Wechsler Intelligence Scale for Children - Third Edition (WISC-III), and the Iowa Gambling Task (IGT). We aim to detect early abnormalities that may predispose individuals who suffered CAM to later psychopathological and cognitive impairments, in the hope that such data may reinforce the need to generate future preventive and rehabilitation interventions in Public Health. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIM, DANIELLE RUIZ; GONCALVES, PRISCILA DIB; OMETTO, MARIELLA; MALBERGIER, ANDRE; AMARAL, RICARDO ABRANTES; DOS SANTOS, BERNARDO; CAVALLET, MIKAEL; CHAIM-AVANCINI, TIFFANY; SERPA, MAURICIO HENRIQUES; KOBUTI FERREIRA, LUIZ ROBERTO; DE SOUZA DURAN, FABIO LUIS; ZANETTI, MARCUS VINICIUS; NICASTR, SERGIO; BUSATTO, GERALDO FILHO; ANDRAD, ARTHUR GUERRA; CUNH, PAULO JANNUZZI. The role of neurocognitive functioning, substance use variables and the DSM-5 severity scale in cocaine relapse: A prospective study. DRUG AND ALCOHOL DEPENDENCE, v. 197, p. 255-261, APR 1 2019. Web of Science Citations: 2.
VIDAL MILIONI, ANA LUIZA; CHAIM, TIFFANY MOUKBEL; CAVALLET, MIKAEL; DE OLIVEIRA, NATHALYA MOLEDA; ANNES, MARCO; DOS SANTOS, BERNARDO; LOUZA, MARIO; DA SILVA, MARIA APARECIDA; MIGUEL, CARMEN SILVIA; SERPA, MAURICIO HENRIQUES; ZANETTI, MARCUS V.; BUSATTO, GERALDO; CUNHA, PAULO JANNUZZI. High IQ May ``Mask{''} the Diagnosis of ADHD by Compensating for Deficits in Executive Functions in Treatment-Naive Adults With ADHD. JOURNAL OF ATTENTION DISORDERS, v. 21, n. 6, p. 455-464, APR 2017. Web of Science Citations: 10.
OMETTO, MARIELLA; DE OLIVEIRA, PAULA APPROBATO; MILIONI, ANA LUIZA; DOS SANTOS, BERNARDO; SCIVOLETTO, SANDRA; BUSATTO, GERALDO F.; NUNES, PAULA V.; CUNHA, PAULO JANNUZZI. Social skills and psychopathic traits in maltreated adolescents. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 25, n. 4, p. 397-405, APR 2016. Web of Science Citations: 6.
PAULO JANNUZZI CUNHA; PAULA APPROBATO DE OLIVEIRA; MARIANA CORTEZZI; GERALDO F. BUSATTO; SANDRA SCIVOLETTO. Executive dysfunction and low academic attainment in adolescent substance abusers with a history of maltreatment. MedicalExpress (São Paulo, online), v. 2, n. 6, p. -, Dez. 2015.

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