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High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study

Abstract

It has been suggested that psychiatric disorders can evolve from an atypical neurodevelopmental process. It is crucial to understand the typical trajectory of neurodevelopment and their periods of greatest vulnerability to study the possible implications of deviations in the pathophysiology of mental disorders. This study aims to evaluate the differences in the trajectories of brain development in healthy children, children at high-risk for mental disorders, children diagnosed with psychopathology at baseline and at three years of follow up. This cohort consists of 750 children aged 7-15 years from the National Institute for Developmental Psychiatry for Children and Adolescents (INCT-INPD). The INPD is the largest national cohort study, and one of the largest international cohorts whose objective is to evaluate the origin of neurodevelopmental atypical trajectory and their expression as mental illness, and also to establish new strategies for prevention and treatment for these disorders. From the initial sample, all subjects will be reassessed 3 years after the baseline using the same battery questionnaires. Clinical evaluation includes, but is not limited to the re-application of DAWBA, M.I.N.I., stressors evaluation and symptom scale. The same individuals who underwent to a Magnetic Resonance Imaging (MRI) at baseline in Sao Paulo (n=375 from a total of 750 of the original cohort) will be invited to repeat the procedure. With the follow-up study we aim to evaluate and identify the profiles of developmental trajectory for both structural and functional aspects of the brain and thus advance the understanding of the pathogenesis of psychiatric disorders. We believe that this study will contribute significantly to new approaches for early detection and risk factors related to mental disorders (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Investigadores de Brasil y de EE.UU. estudian los efectos del estrés tóxico en niños 
Articles published in Pesquisa FAPESP Magazine about the research grant:
Depresión adolescente 
Adolescent depression 
Una larga maduración 
A long maturation period 

Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BATISTUZZO, MARCELO C.; SOTTILI, BRUNA A.; SHAVITT, ROSELI G.; LOPES, ANTONIO C.; CAPPI, CAROLINA; DE MATHIS, MARIA ALICE; PASTORELLO, BRUNO; DINIZ, JULIANA B.; SILVA, RENATA M. F.; MIGUEL, EURIPEDES C.; HOEXTER, MARCELO Q.; OTADUY, MARIA C. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive-Compulsive Disorder. FRONTIERS IN PSYCHIATRY, v. 12, JUN 8 2021. Web of Science Citations: 0.
VATTIMO, EDOARDO F. Q.; DOS SANTOS, ALLAN CHRISTIANO; HOEXTER, MARCELO Q.; FRUDIT, PAULA; MIGUEL, EURIPEDES C.; SHAVITT, ROSELI G.; BATISTUZZO, MARCELO C. Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 307, JAN 30 2021. Web of Science Citations: 0.
DE ARAUJO, CELIA MARIA; SWARDFAGER, WALTER; ZUGMAN, ANDRE; COGO-MOREIRA, HUGO; BELANGERO, SINTIA I.; OTA, VANESSA K.; SPINDOLA, LETICIA M.; HAKONARSON, HAKON; PELLEGRINO, RENATA; GADELHA, ARY; SALUM, GIOVANNI A.; PAN, PEDRO M.; MANSUR, RODRIGO B.; HOEXTER, MARCELO; PICON, FELIPE; SATO, JOAO R.; BRIETZKE, ELISA; GRASSI-OLIVEIRA, RODRIGO; ROHDE, LUIS A. P.; MIGUEL, EURIPEDES C.; BRESSAN, RODRIGO A.; JACKOWSKI, ANDREA P. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?. CNS SPECTRUMS, v. 25, n. 6, p. 790-796, DEC 2020. Web of Science Citations: 0.
BIAZOLI JR, CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; REBELLO, KEILA; MOURA, LUCIANA MONTEIRO; PAN, PEDRO MARIO; BRIETZKE, ELISA; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; BRESSAN, RODRIGO AFFONSECA; JACKOWSKI, ANDREA PAROLIN; SATO, JOAO RICARDO. Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus. BRAIN IMAGING AND BEHAVIOR, v. 14, n. 4, p. 961-970, AUG 2020. Web of Science Citations: 1.
REBELLO, KEILA; MOURA, LUCIANA M.; XAVIER, GABRIELA; SPINDOLA, LETICIA M.; CARVALHO, CAROLINA MUNIZ; HOEXTER, MARCELO QUEIROZ; GADELHA, ARY; PICON, FELIPE; PAN, PEDRO MARIO; ZUGMAN, ANDRE; GRASSI-OLIVEIRA, RODRIGO; BRIETZKE, ELISA; BELANGERO, I, SINTIA; SALUM, GIOVANNI ABRAHAO; ROHDE, LUIS AUGUSTO; MIGUEL, EURIPEDES CONSTANTINO; BRESSAN, RODRIGO; JACKOWSKI, ANDREA; SATO, JOAO RICARDO. Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence. JOURNAL OF PSYCHOSOMATIC RESEARCH, v. 127, DEC 2019. Web of Science Citations: 0.
VATTIMO, EDOARDO F. Q.; BARROS, VIVIAN B.; REQUENA, GUARACI; SATO, JOAO R.; FATORI, DANIEL; MIGUEL, EURIPEDES C.; SHAVITT, ROSELI G.; HOEXTER, MARCELO Q.; BATISTUZZO, MARCELO C. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 28, n. 12, p. 1607-1617, DEC 2019. Web of Science Citations: 1.
SATO, JOAO RICARDO; BIAZOLI JR, CLAUDINEI EDUARDO; MOURA, LUCIANA MONTEIRO; CROSSLEY, NICOLAS; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; HOEXTER, MARCELO QUEIROZ; AMARO JR, EDSON; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; BRESSAN, RODRIGO AFFONSECA; JACKOWSKI, ANDREA PAROLIN. Association Between Fractional Amplitude of Low-Frequency Spontaneous Fluctuation and Degree Centrality in Children and Adolescents. BRAIN CONNECTIVITY, v. 9, n. 5, p. 379-387, JUN 1 2019. Web of Science Citations: 0.
SATO, JOAO RICARDO; BIAZOLI JR, CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; AMARO JR, EDSON; ANES, MAURICIO; MOURA, LUCIANA MONTEIRO; GOMES DEL'AQUILLA, MARCO ANTONIO; MCGUIRE, PHILIP; ROHDEZ, LUIS AUGUSTO; MIGUEL, EURIPEDES CONSTANTINO; BRESSAN, RODRIGO AFFONSECA; JACKOWSKI, ANDREA PAROLIN. Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 28, n. 6, p. 835-845, JUN 2019. Web of Science Citations: 0.
DE MOURA, ADRIANA MIYAZAKI; LOPEZ PINAYA, WALTER HUGO; GADELHA, ARY; ZUGMAN, ANDRE; NOTO, CRISTIANO; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; SATO, JOAO RICARDO. Investigating brain structural patterns in first episode psychosis and schizophrenia using MRI and a machine learning approach. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 275, p. 14-20, MAY 30 2018. Web of Science Citations: 0.
DE ARAUJO, CELIA MARIA; ZUGMAN, ANDRE; SWARDFAGER, WALTER; NOGUEIRA BELANGERO, SINTIA IOLE; OTA, VANESSA KIYOMI; SPINDOLA, LETICIA MARIA; HAKONARSON, HAKON; PELLEGRINO, RENATA; GADELHA, ARY; SALUM, GIOVANNI ABRAHAO; PAN, PEDRO MARIO; DE MOURA, LUCIANA MONTEIRO; DEL AQUILLA, MARCO; PICON, FELIPE ALMEIDA; AMARO, JR., EDSON; SATO, JOAO RICARDO; BRIETZKE, ELISA; GRASSI-OLIVEIRA, RODRIGO; ROHDE, LUIS AUGUSTO P.; MIGUEL, EURIPEDES CONSTANTINO; BRESSAN, RODRIGO A.; JACKOWSKI, ANDREA PAROLIN. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. JOURNAL OF PSYCHIATRIC RESEARCH, v. 98, p. 51-58, MAR 2018. Web of Science Citations: 6.
HOEXTER, MARCELO Q.; BIAZOLI, JR., CLAUDINEI E.; ALVARENGA, PEDRO G.; BATISTUZZO, MARCELO C.; SALUM, GIOVANNI A.; GADELHA, ARY; PAN, PEDRO M.; ANES, MAURICIO; MANCINI-MARTINS, LETICIA; MOURA, LUCIANA M.; SORIANO-MAS, CARIES; AQUILLA, MARCO A. G. DEL'; ARNARO, JR., EDSON; ROHDE, LUIS A.; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; MIGUEL, EURIPEDES C.; DO ROSARIO, MARIA C.; SATO, JOAO R. Low frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sample. JOURNAL OF PSYCHIATRIC RESEARCH, v. 96, p. 224-230, JAN 2018. Web of Science Citations: 1.
SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; AMARO, JR., EDSON; ANES, MAURICIO; MOURA, LUCIANA MONTEIRO; GOMES DEL'AQUILLA, MARCO ANTONIO; MCGUIRE, PHILIP; ROHDE, LUIS AUGUSTO; MIGUEL, EURIPEDES CONSTANTINO; JACKOWSKI, ANDREA PAROLIN; BRESSAN, RODRIGO AFFONSECA. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 19, n. 2, p. 119-129, 2018. Web of Science Citations: 2.
PAN, PEDRO MARIO; SATO, JOAO R.; SALUM, GIOVANNI A.; ROHDE, LUIS A.; GADELHA, ARY; ZUGMAN, ANDRE; MARI, JAIR; JACKOWSKI, ANDREA; PICON, FELIPE; MIGUEL, EURIPEDES C.; PINE, DANIEL S.; LEIBENLUFT, ELLEN; BRESSAN, RODRIGO A.; STRINGARIS, ARGYRIS. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal of Psychiatry, v. 174, n. 11, p. 1112-1119, NOV 1 2017. Web of Science Citations: 24.
MOURA, L. M.; CROSSLEY, N. A.; ZUGMAN, A.; PAN, P. M.; GADELHA, A.; DEL AQUILLA, M. A. G.; PICON, F. A.; ANES, M.; AMARO, JR., E.; DE JESUS MARI, J.; MIGUEL, E. C.; ROHDE, L. A.; BRESSAN, R. A.; MCGUIRE, P.; SATO, J. R.; JACKOWSKI, A. P. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. BRAIN IMAGING AND BEHAVIOR, v. 11, n. 3, p. 808-817, JUN 2017. Web of Science Citations: 5.
SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; ANES, MAURICIO; MOURA, LUCIANA MONTEIRO; GOMES DEL'AQUILLA, MARCO ANTONIO; AMARO JUNIOR, EDSON; MCGUIRE, PHILIP; ROHDE, LUIS AUGUSTO; MIGUEL, EURIPEDES CONSTANTINO; BRESSAN, RODRIGO AFFONSECA; JACKOWSKI, ANDREA PAROLIN. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation. DEVELOPMENTAL COGNITIVE NEUROSCIENCE, v. 20, p. 2-11, AUG 2016. Web of Science Citations: 3.
MOURA, LUCIANA MONTEIRO; KEMPTON, MATTHEW; BARKER, GARETH; SALUM, GIOVANNI; GADELHA, ARY; PAN, PEDRO MARIO; HOEXTER, MARCELO; GOMES DEL AQUILLA, MARCO ANTONIO; PICON, FELIPE ALMEIDA; ANES, MAURICIO; GARCIA OTADUY, MARIA CONCEPCION; AMARO, JR., EDSON; ROHDE, LUIS AUGUSTO; MCGUIRE, PHILIP; BRESSAN, RODRIGO AFFONSECA; SATO, JOAO RICARDO; JACKOWSKI, ANDREA PAROLIN. Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence. MAGNETIC RESONANCE IMAGING, v. 34, n. 4, p. 529-534, MAY 2016. Web of Science Citations: 8.
SATO, JOAO RICARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; MANFRO, GISELE GUS; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; ANES, MAURICIO; MOURA, LUCIANA MONTEIRO; GOMES DEL'AQUILLA, MARCO ANTONIO; AMARO, JR., EDSON; MCGUIRE, PHILIP; TAVARES LACERDA, ACIOLY LUIZ; ROHDE, LUIS AUGUSTO; MIGUEL, EURIPEDES CONSTANTINO; JACKOWSKI, ANDREA PAROLIN; BRESSAN, RODRIGO AFFONSECA. Default mode network maturation and psychopathology in children and adolescents. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. 57, n. 1, p. 55-64, JAN 2016. Web of Science Citations: 10.
ANDRÉ ZUGMAN; JOÃO R. SATO; ANDREA P. JACKOWSKI. Crisis in neuroimaging: is neuroimaging failing 15 years after the decade of the brain?. Revista Brasileira de Psiquiatria, v. 38, n. 4, p. 267-269, Dez. 2016.

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