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Modifications in plasma levels of BDNF and BDNF gene polymorphisms in patients with OCD submitted to fear conditioning paradigm

Grant number: 12/09648-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2012
Effective date (End): August 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Juliana Belo Diniz
Grantee:Karina Soares de Oliveira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

It is believed that the physiopathology of obsessive-compulsive disorder (OCD) is associated with a deficiency in inhibitory neuronal processes and fear extinction. In patients with OCD, it was found that plasma levels of brain derived neurotrophic factor (BDNF) are smaller than in healthy subjects and the allelic variant of the gene that encodes it, known as BDNF met66val, is associated with early onset and severity of obsessive-compulsive symptoms, and other phenotypic characteristics of this disorder. The expression of BDNF is essential to the mechanism of memory and learning, through processes related to neuronal plasticity and a possible relationship of the activity of BDNF and anxiety disorders, over its ability to promote learning of extinction of fear conditioning response. The project aims to assess the plasma levels of BDNF before and after the procedure of fear conditioning and verify whether these levels correlate to retention of extinction learning after 24 hours. Besides, seven markers related to the BDNF gene will be surveyed, to evaluate their relationship to the presence or absence of OCD. Patients with OCD and control will be submitted to a process of extinction of fear conditioning and blood samples will be performed. Plasma levels of BDNF will be evaluated by ELISA and the seven markers will be genotyped by real-time PCR using TaqMan system.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KARINA SOARES DE OLIVEIRA; ANA GABRIELA HOUNIE; CAROLINA CAPPI; JULIANA BELO DINIZ. Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety. Jornal Brasileiro de Psiquiatria, v. 65, n. 3, p. -, Set. 2016.
REIMER, ADRIANO EDGAR; DE OLIVEIRA, AMANDA RIBEIRO; DINIZ, JULIANA BELO; HOEXTER, MARCELO QUEIROZ; CHIAVEGATTO, SILVANA; BRANDAO, MARCUS LIRA. Rats with differential self-grooming expression in the elevated plus-maze do not differ in anxiety-related behaviors. Behavioural Brain Research, v. 292, p. 370-380, OCT 1 2015. Web of Science Citations: 11.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.