International joint research on the development and application of electroretinographic and psychophysical methods for the assessment of postreceptoral on-and off-mechanisms in both chromatic and luminance retinal visual pathways in Duchenne muscular dystrophy and in Diabetes mellitus

• Processo: 12/51299-3
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de fevereiro de 2013
• Data de Término da vigência: 31 de janeiro de 2015
• Área do conhecimento: Ciências Humanas - Psicologia - Psicologia Experimental
• Acordo de Cooperação: BAYLAT/StMBW - Bavarian Academic Center for Latin America and Bavarian State Ministry of Science and the Arts
• Pesquisador responsável: Dora Selma Fix Ventura
• Beneficiário: Dora Selma Fix Ventura
• Pesquisador Responsável no exterior: Jan Kremers
• Instituição Parceira no exterior: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Alemanha
• Instituição Sede: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Assunto(s): Distrofia muscular de Duchenne Diabetes mellitus Eletrorretinografia Retina
• Palavra(s)-Chave do Pesquisador: Diabetes Mellites | Duchennes Muscular Dystrophy | Electroretinography | Psychophysics | Retina

Resumo

Diabetes mellitus and Duchenne muscular dystrophy are diseases that affect many organ systems in the body, including the retina. The objective of the proposed project is to obtain a more comprehensive and detailed understanding of the pathophysiological mechanisms in the human retina associated with these two important diseases. Our approach will be to use modern electrophysiological and psychophysical techniques that selectively reflect the activity of post-receptoral retinal mechanisms. The techniques are designed to specifically tap post-receptoral mechanisms associated with distinct retino-geniculate pathways that subserve different sensory-perceptual features: spatiotemporal luminance (achromatic) and chromatic vision. The results of the project will quantify the alterations caused by these diseases in these visual pathways, clarify the nature and locus of alterations in the underlying retinal neural substrate and bring the data in a context that is relevant for visual perception. (AU)

Publicações científicas

(5)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; NAGY, BALAZS VINCE; TSAI, TINA; DAMICO, FRANCISCO MAX; DA COSTA, MARCELO FERNANDES; PAVANELLO, RITA DE CASSIA M.; VILACA LOURENCO, NAILA CRISTINA; PEREIRADE CERQUEIRA, ANTONIA MARIA; ZATZ, MAYANA; et al. Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 8, p. 3581-3587, JUL 2016. (14/26818-2, 12/51299-3, 12/01115-3, 14/06457-5, 13/08028-1)

TSAI, TINA I.; SALGUEIRO BARBONI, MIRELLA TELLES; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; VENTURA, DORA FIX; KREMERS, JAN. Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx(3Cv) Mouse Model of Duchenne Muscular Dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 13, p. 5788-5798, OCT 2016. (14/06457-5, 12/51299-3, 07/55125-1, 12/01115-3)

HUCHZERMEYER, CORD; MARTINS, CRISTIANE M. G.; NAGY, BALAZS; BARBONI, MIRELLA T. S.; VENTURA, DORA F.; COSTA, MARCELO F.; KREMERS, JAN. Photoreceptor-specific light adaptation of critical flicker frequency in trichromat and dichromat observers. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B106-B113, APR 1 2018. (14/26818-2, 16/22007-5, 12/51299-3, 14/06457-5)

NAGY, BALAZS VINCE; SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; DA COSTA, MARCELO FERNANDES; KREMERS, JAN; VENTURA, DORA FIX. Human flicker electroretinography using different temporal modulations at mesopic and photopic luminance levels. DOCUMENTA OPHTHALMOLOGICA, v. 129, n. 2, p. 129-138, OCT 2014. (09/54292-7, 08/58731-2, 07/55125-1, 12/51299-3, 12/01115-3)

TSAI, TINA I.; BARBONI, MIRELLA TELLES SALGUEIRO; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; KREMERS, JAN J.. Asymmetrical ON/OFF retinal dysfunction in the mdx(Cv3) mouse model of Duchenne muscular dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 12, p. 3-pg., 2016-09-01. (14/06457-5, 12/51299-3, 12/01115-3, 07/55125-1)