International joint research on the development and application of electroretinographic and psychophysical methods for the assessment of postreceptoral on-and off-mechanisms in both chromatic and luminance retinal visual pathways in Duchenne muscular dystrophy and in Diabetes mellitus

• Grant number: 12/51299-3
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2013
• End date: January 31, 2015
• Field of knowledge: Humanities - Psychology - Experimental Psychology
• Agreement: BAYLAT/StMBW - Bavarian Academic Center for Latin America and Bavarian State Ministry of Science and the Arts
• Principal Investigator: Dora Selma Fix Ventura
• Grantee: Dora Selma Fix Ventura
• Principal researcher abroad: Jan Kremers
• Institution abroad: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany
• Host Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Diabetes mellitus and Duchenne muscular dystrophy are diseases that affect many organ systems in the body, including the retina. The objective of the proposed project is to obtain a more comprehensive and detailed understanding of the pathophysiological mechanisms in the human retina associated with these two important diseases. Our approach will be to use modern electrophysiological and psychophysical techniques that selectively reflect the activity of post-receptoral retinal mechanisms. The techniques are designed to specifically tap post-receptoral mechanisms associated with distinct retino-geniculate pathways that subserve different sensory-perceptual features: spatiotemporal luminance (achromatic) and chromatic vision. The results of the project will quantify the alterations caused by these diseases in these visual pathways, clarify the nature and locus of alterations in the underlying retinal neural substrate and bring the data in a context that is relevant for visual perception. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; NAGY, BALAZS VINCE; TSAI, TINA; DAMICO, FRANCISCO MAX; DA COSTA, MARCELO FERNANDES; PAVANELLO, RITA DE CASSIA M.; VILACA LOURENCO, NAILA CRISTINA; PEREIRADE CERQUEIRA, ANTONIA MARIA; ZATZ, MAYANA; et al. Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 8, p. 3581-3587, JUL 2016. (14/26818-2, 12/51299-3, 12/01115-3, 14/06457-5, 13/08028-1)

TSAI, TINA I.; SALGUEIRO BARBONI, MIRELLA TELLES; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; VENTURA, DORA FIX; KREMERS, JAN. Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx(3Cv) Mouse Model of Duchenne Muscular Dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 13, p. 5788-5798, OCT 2016. (14/06457-5, 12/51299-3, 07/55125-1, 12/01115-3)

HUCHZERMEYER, CORD; MARTINS, CRISTIANE M. G.; NAGY, BALAZS; BARBONI, MIRELLA T. S.; VENTURA, DORA F.; COSTA, MARCELO F.; KREMERS, JAN. Photoreceptor-specific light adaptation of critical flicker frequency in trichromat and dichromat observers. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B106-B113, APR 1 2018. (14/26818-2, 16/22007-5, 12/51299-3, 14/06457-5)

NAGY, BALAZS VINCE; SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; DA COSTA, MARCELO FERNANDES; KREMERS, JAN; VENTURA, DORA FIX. Human flicker electroretinography using different temporal modulations at mesopic and photopic luminance levels. DOCUMENTA OPHTHALMOLOGICA, v. 129, n. 2, p. 129-138, OCT 2014. (08/58731-2, 07/55125-1, 12/51299-3, 12/01115-3)

TSAI, TINA I.; BARBONI, MIRELLA TELLES SALGUEIRO; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; KREMERS, JAN J.. Asymmetrical ON/OFF retinal dysfunction in the mdx(Cv3) mouse model of Duchenne muscular dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 12, p. 3-pg., 2016-09-01. (14/06457-5, 12/51299-3, 12/01115-3, 07/55125-1)