Development and application of electroretinographic and psychophysical methods for the assessment of on and off mechanisms in both chromatic and luminance visual pathways in Diabetes Mellitus and Duchenne muscular dystrophy

• Grant number: 12/01115-3
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: October 31, 2014
• Field of knowledge: Humanities - Psychology - Experimental Psychology
• Principal Investigator: Dora Selma Fix Ventura
• Grantee: Dora Selma Fix Ventura
• Host Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Diabetes mellitus and Duchenne muscular dystrophy are diseases that affect many organ systems in the body, including the retina. The objective of the proposed project is to obtain a more comprehensive and detailed understanding of the pathophysiological mechanisms in the human retina associated with these two important diseases. Our approach will be to use modern electrophysiological and psychophysical techniques that selectively reflect the activity of post-receptoral retinal mechanisms. The techniques are designed to specifically tap post-receptoral mechanisms associated with distinct retino-geniculate pathways that subserve different sensory-perceptual features: spatiotemporal luminance (achromatic) and chromatic vision. The results of the project will quantify the alterations caused by these diseases in these visual pathways and help clarify the nature and locus of alterations in the underlying retinal neural substrate. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; NAGY, BALAZS VINCE; TSAI, TINA; DAMICO, FRANCISCO MAX; DA COSTA, MARCELO FERNANDES; PAVANELLO, RITA DE CASSIA M.; VILACA LOURENCO, NAILA CRISTINA; PEREIRADE CERQUEIRA, ANTONIA MARIA; ZATZ, MAYANA; et al. Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 8, p. 3581-3587, JUL 2016. (14/26818-2, 12/51299-3, 12/01115-3, 14/06457-5, 13/08028-1)

GOMES MARTINS, CRISTIANE MARIA; TSAI, TINA; SALGUEIRO BARBONI, MIRELLA TELLES; DA COSTA, MARCELO FERNANDES; NAGY, BALAZS; VENTURA, DORA FIX; KREMERS, JAN. The influence of stimulus size on heterochromatic modulation electroretinograms. JOURNAL OF VISION, v. 16, n. 8, JUN 2016. (12/01115-3, 07/55125-1, 14/06457-5)

TSAI, TINA I.; SALGUEIRO BARBONI, MIRELLA TELLES; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; VENTURA, DORA FIX; KREMERS, JAN. Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx(3Cv) Mouse Model of Duchenne Muscular Dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 13, p. 5788-5798, OCT 2016. (14/06457-5, 12/51299-3, 07/55125-1, 12/01115-3)

NAGY, BALAZS VINCE; SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; DA COSTA, MARCELO FERNANDES; KREMERS, JAN; VENTURA, DORA FIX. Human flicker electroretinography using different temporal modulations at mesopic and photopic luminance levels. DOCUMENTA OPHTHALMOLOGICA, v. 129, n. 2, p. 129-138, OCT 2014. (08/58731-2, 07/55125-1, 12/51299-3, 12/01115-3)

ZACHI, ELAINE C.; COSTA, THIAGO L.; BARBONI, MIRELLA T. S.; COSTA, MARCELO F.; BONCI, DANIELA M. O.; VENTURA, DORA F.. Color Vision Losses in Autism Spectrum Disorders. FRONTIERS IN PSYCHOLOGY, v. 8, JUN 30 2017. (12/01115-3)

TSAI, TINA I.; BARBONI, MIRELLA TELLES SALGUEIRO; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; KREMERS, JAN J.. Asymmetrical ON/OFF retinal dysfunction in the mdx(Cv3) mouse model of Duchenne muscular dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 12, p. 3-pg., 2016-09-01. (14/06457-5, 12/51299-3, 12/01115-3, 07/55125-1)