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Cannabidiol regulation of fear memory processing and associated brain function

Processo: 12/50896-8
Modalidade de apoio:Auxílio à Pesquisa - Regular
Vigência: 01 de fevereiro de 2013 - 31 de janeiro de 2015
Área do conhecimento:Ciências Biológicas - Farmacologia - Neuropsicofarmacologia
Convênio/Acordo: University of Birmingham ; University of Nottingham
Pesquisador responsável:Francisco Silveira Guimaraes
Beneficiário:Francisco Silveira Guimaraes
Pesq. responsável no exterior: Carl William Stevenson
Instituição no exterior: University of Nottingham, University Park, Inglaterra
Pesq. responsável no exterior: Jonathan Loon Choon Lee
Instituição no exterior: University of Birmingham, Inglaterra
Instituição Sede: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
Vinculado ao auxílio:07/03685-3 - Neurotransmissores típicos e atípicos em transtornos neuropsiquiátricos, AP.TEM
Assunto(s):Transtornos de ansiedade  Memória (psicologia)  Medo  Córtex pré-frontal  Canabidiol 
Palavra(s)-Chave do Pesquisador:Anxiety | Cannabidiol | Endocannabinoid | Fear Memory | Hippocampus | Prefrontal Cortex

Resumo

Anxiety disorders such as phobias and post-traumatic stress are common and often debilitating diseases linked to abnormally persistent memories of fearful events. Although psychological and drug therapies are available, these treatments show limited effectiveness and can cause adverse side effects, highlighting the urgent need for better therapies to treat these disorders. Cannabidiol, the main non-psychotropic phytocannabinoid present in the Cannabis sativa plant, is a drug that has shown great promise for treating anxiety disorders. We have shown that cannabidiol reduces fear in various animal models of anxiety and have recently extended these findings to show that it also reduces fear memory expression. Interestingly, cannabidiol has also been shown to enhance fear memory extinction, the process by which psychological therapy can reduce fear memory persistence. However, the pharmacological mechanisms and brain sites involved in mediating these effects remain unclear or unknown. In this multi-disciplinary project we will combine behavioral, pharmacological, electrophysiological and molecular biology techniques to determine the neurochemical and neural circuit mechanisms underlying the effects of cannabidiol on fear memory processing. Specifically, we will examine the roles of endocannabinoid transmission and prefrontal cortex-hippocampus circuit function in mediating the effects of cannabidiol on the expression and extinction of contextual fear memory in rats. Understanding the basic mechanisms underlying cannabidiol's effects on behaviour and brain function has important translational implications for its potential use in treating anxiety. (AU)

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Publicações científicas (5)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
FOGACA, M. V.; REIS, F. M. C. V.; CAMPOS, A. C.; GUIMARAES, F. S.. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: Involvement of 5HT(1A) receptors and previous stressful experience. European Neuropsychopharmacology, v. 24, n. 3, p. 410-419, . (12/50896-8, 12/17626-7)
FOGACA, MANOELA V.; SONEGO, ANDREZA B.; RIOLI, VANESSA; GOZZO, FABIO C.; DALE, CAMILA S.; FERRO, EMER S.; GUIMARAES, FRANCISCO S.. Anxiogenic-like effects induced by hemopressin in rats. Pharmacology Biochemistry and Behavior, v. 129, p. 7-13, . (12/50896-8, 12/17626-7)
LEE, JONATHAN L. C.; BERTOGLIO, LEANDRO J.; GUIMARAES, FRANCISCO S.; STEVENSON, CARL W.. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. British Journal of Pharmacology, v. 174, n. 19, SI, p. 3242-3256, . (12/50896-8)
JURKUS, REGIMANTAS; DAY, HARRIET L. L.; GUIMARAES, FRANCISCO S.; LEE, JONATHAN L. C.; BERTOGLIO, LEANDRO J.; STEVENSON, CARL W.. Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders. FRONTIERS IN PHARMACOLOGY, v. 7, . (12/50896-8)
BATISTA, PRISCILA A.; FOGACA, MANOELA V.; GUIMARAES, FRANCISCO S.. The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors. Behavioural Brain Research, v. 293, p. 182-188, . (12/50896-8, 12/17626-7)

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