Phenotypic analysis of seizure-induced cell proliferation

• Processo: 01/00142-2
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Data de Início da vigência: 10 de agosto de 2001
• Data de Término da vigência: 09 de agosto de 2002
• Área de conhecimento: Ciências Biológicas - Fisiologia - Fisiologia de Órgãos e Sistemas
• Pesquisador responsável: Fulvio Alexandre Scorza
• Beneficiário: Fulvio Alexandre Scorza
• Pesquisador Anfitrião: Daniel Henry Lowenstein
• Instituição Sede: Centro de Ciências Biomédicas. Universidade de Mogi das Cruzes (UMC). Mogi das Cruzes , SP, Brasil
• Instituição Anfitriã: Harvard University, Boston, Estados Unidos
• Palavra(s)-Chave do Pesquisador: Dentate Gyrus | Epilepsy | Neurogenesis | Plasticity | Rat

Resumo

This research is designed to explore the biological basis of seizure-induced neurogenesis in the mature central nervous system (CNS) and the role of neurogenesis in the pathophysiology of epilepsy. Previous work has demonstrated that various forms of experimental seizures paradigms, lead to a marked increase in the mitotic activity of precursor cell located at the subgranular zone of the adult dentate gyrus which differentiates into mature dentate granule cells. The aim of this study is to verify the factors determining cell fate during the normal, early development of the CNS involved in controlling the lineage of newly-born cells after seizures. These experiments will lead to our understanding the seizure- induced plasticity and the factors that control precursor cell fate in the adult animal following seizures. (AU)