The emerging role of extracellular vesicles as biomarkers for urogenital cancers

Autor(es):Mostrar menos -

Nawaz, Muhammad ^[1] ; Camussi, Giovanni ^[2] ; Valadi, Hadi ^[3] ; Nazarenko, Irina ^[4] ; Ekstrom, Karin ^[3] ; Wang, Xiaoqin ^[3] ; Principe, Simona ^[5] ; Shah, Neelam ^[6] ; Ashraf, Naeem M. ^[7] ; Fatima, Farah ^[1] ; Neder, Luciano ^[1] ; Kislinger, Thomas ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, BR-05508 Sao Paulo - Brazil

^[2] Univ Turin, I-10124 Turin - Italy

^[3] Univ Gothenburg, BIOMATCELL VINN Excellence Ctr Biomat & Cell Ther, Gothenburg - Sweden

^[4] Univ Med Ctr Freiburg, Freiburg - Germany

^[5] Princess Margaret Canc Ctr, Toronto, ON M5G 1L7 - Canada

^[6] Monash Univ, Clayton, Vic 3800 - Australia

^[7] Univ Gujrat, Gujrat - Pakistan

• Tipo de documento: Artigo de Revisão
• Fonte: NATURE REVIEWS UROLOGY; v. 11, n. 12, p. 688-701, DEC 2014.
• Citações Web of Science: 111

Resumo

The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets. (AU)

• Processo FAPESP: 12/24574-3 - Perfil de citocinas na infecção pelo vírus da dengue: identificação de potenciais biomarcadores para diagnóstico e prognóstico
• Beneficiário: Muhammad Nawaz
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto