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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Swimming training promotes cardiac remodeling and alters the expression of mRNA and protein levels involved in calcium handling in hypertensive rats

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Autor(es):
Locatelli, Jamille [1] ; Monteiro de Assis, Leonardo Vinicius [2] ; Araujo, Carolina Morais [3] ; Alzamora, Andreia Carvalho [4] ; de Lima, Wanderson Geraldo [5] ; Campagnole-Santos, Maria Jose [6] ; dos Santos, Robson Augusto [7] ; Isoldi, Mauro Cesar [8]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Ouro Preto. Ctr Res Biol Sci
[2] Univ Sao Paulo. Inst Biosci
[3] Univ Fed Ouro Preto. Ctr Res Biol Sci
[4] Univ Fed Ouro Preto. Ctr Res Biol Sci
[5] Univ Fed Ouro Preto. Ctr Res Biol Sci
[6] Natl Inst Sci & Technol Nanobiopharmaceut Innovat. Belo Horizonte
[7] Natl Inst Sci & Technol Nanobiopharmaceut Innovat. Belo Horizonte
[8] Univ Fed Ouro Preto. Ctr Res Biol Sci
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 117, n. 2, p. 67-74, NOV 11 2014.
Citações Web of Science: 8
Resumo

Aim: The aim of this study was to identify the effects of swimming training on the mRNA expression and protein levels of the calcium handling proteins in the hearts of renovascular hypertensive rats submitted to swimming protocol during 6 weeks. Main methods: Fischer rats with renovascular hypertension 2-kidney 1-clip (2K1 C) and SHAM groups were divided among sedentary and exercised groups. The exercise protocol lasted for 6 weeks (1 h/day, 5x/week), and the mean arterial pressure, cardiomyocytes hypertrophy parameters, mRNA expression and protein levels of some calcium handling proteins in the left ventricle were evaluated. Key findings: Swimming training was able to reduce the levels of mean arterial pressure in the hypertensive group compared to 2K1C SED, and to promote cardiac hypertrophy in SHAM EX and 2K1C EX groups in comparison to the respective control groups. The mRNA levels of B-type natriuretic peptide were reduced in the 2K1C EX when compared to 2K1C SED. The mRNA and protein levels of the sarcoplasmic reticulum Ca2+-ATPase increased after the swimming training in SHAM and 2K1C groups. The mRNA and protein levels of phospholamban, displayed an increase in their levels in the exercised SHAM and in hypertensive rats in comparison to their respective controls; while mRNA levels of Na+/Ca2+ exchanger was reduced in the left ventricle comparing to the sedentary hypertensive rats. Significance: Taken altogether, we provide evidence that the aerobic training may lead to cardiac remodeling, and modulate the calcium handling proteins expression in the heart of hypertensive rats. (C) 2014 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 13/24337-4 - Mecanismos de modulação de genes de relógio em melanócitos normais (melan-A) e transformados (melanoma B16-F10) por UVA e luz azul
Beneficiário:Leonardo Vinícius Monteiro de Assis
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto