Neuronal excitability level transition induced by electrical stimulation

Autor(es)

Florence, G. ^{[1, 2, 3, 4]} ; Kurths, J. ^{[3, 4]} ; Machado, B. S. ^[5] ; Fonoff, E. T. ^[1] ; Cerdeira, H. A. ^[6] ; Teixeira, M. J. ^[1] ; Sameshima, K. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Neurol, LIM 43, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, LIM 43, Sao Paulo - Brazil

^[3] Humboldt Univ, Inst Phys, D-10099 Berlin - Germany

^[4] Potsdam Inst Climate Impact Res, Potsdam - Germany

^[5] Hosp Israelita Albert Einstein, Inst Brain, Sao Paulo - Brazil

^[6] Univ Estadual Paulista, Inst Fis Teor, BR-01405 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Physical Journal-Special Topics; v. 223, n. 13, p. 2913-2922, DEC 2014.
• Citações Web of Science: 1

Resumo

In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders. (AU)

• Processo FAPESP: 11/21138-5 - Análise de padrões oscilatórios de registros intracirúrgicos em Estimulação Cerebral Profunda para Doença de Parkinson
• Beneficiário: Gerson Florence Carvalheira de Azevedo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado