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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Atorvastatin administered before myocardial infarction in rats improves contractility irrespective of metabolic changes

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Autor(es):
Lehnen, Tatiana Ederich [1, 2, 3] ; Lehnen, Alexandre Machado [1, 2, 3] ; Vicente Tavares, Angela Maria [4] ; Bello-Klein, Adriane [4] ; Markoski, Melissa Medeiros [3] ; Machado, Ubiratan Fabres [5] ; Schaan, Beatriz [1, 2, 3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Rio Grande do Sul, Postgrad Program Endocrinol, Porto Alegre, RS - Brazil
[2] Hosp Clin Porto Alegre, Div Endocrine, BR-90035003 Porto Alegre, RS - Brazil
[3] Univ Fdn Cardiol Rio Grande Sul, Inst Cardiol, Porto Alegre, RS - Brazil
[4] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Lab Cardiovasc Physiol, Porto Alegre, RS - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Clinical and Experimental Pharmacology and Physiology; v. 41, n. 12, p. 986-994, DEC 2014.
Citações Web of Science: 4
Resumo

Statins have a beneficial effect after myocardial infarction, but the relationship between glucose transporters and their use before the event has not yet been studied. We assessed the effects of atorvastatin treatment pre- and post-myocardial infarction on cardiovascular function and glucose transporter 4 (GLUT4) in the heart. Wistar-Kyoto rats were treated with 20 mg/kg atorvastatin or vehicle for 14 days before coronary artery occlusion surgery (myocardial infarction) or sham surgery. Echocardiographic evaluations were carried out 48 h after myocardial infarction (protocol A) and after 7 days (protocol B), when atorvastatin was also administered. Plasma inflammatory markers and GLUT4 in the heart were also evaluated. Animals were divided into the following groups: sham-operated and vehicle (C), myocardial infarction and vehicle (I), sham-operated and atorvastatin (CAt) and myocardial infarction and atorvastatin (IAt). After 48 h, myocardial infarction induced higher left ventricular fractional shortening in IAt versus I (similar to 60%, P = 0.036), and the ejection fraction was lower (protocol A similar to 37%; protocol B similar to 30%). Myocardial infarction was associated with a rise in plasma membrane GLUT4 after 48 h (similar to 40%, P < 0.001), and a reduction in GLUT4 after 7 days (I 25%; IAt 49%, P < 0.001). Atorvastatin treatment for 48 h after the infarction did not change GLUT4 expression, and after 7 days it had an additional negative effect on GLUT4 content (similar to 39%, P = 0.030). In conclusion, atorvastatin treatment pre- and post-myocardial infarction improved myocardial contractility after 48 h, but not after 7 days, and was not associated with an increase in GLUT4 expression. (AU)

Processo FAPESP: 12/04831-1 - Novos moduladores do controle glicêmico e do desenvolvimento de complicações crônicas no Diabetes mellitus: perspectivas preventivas e terapêuticas
Beneficiário:Ubiratan Fabres Machado
Linha de fomento: Auxílio à Pesquisa - Temático