Frequencies of allele groups HLA-A, HLA-B and HLA-DRB1 in a population from the northwestern region of Sao Paulo State, Brazil

Autor(es)

Ayo, C. M. ^[1] ; da Silveira Camargo, A. V. ^[2] ; Xavier, D. H. ^[3] ; Batista, M. F. ^[4] ; Carneiro, O. A. ^[5] ; Brandao de Mattos, C. C. ^[6] ; Ricci, Jr., O. ; de Mattos, L. C. ^[8]

Afiliação do(s) autor(es)

^[1] Fac Med Sao Jose do Rio Preto FAMERP. Dept Biol Mol

^[2] Fac Med Sao Jose do Rio Preto FAMERP. Dept Biol Mol

^[3] Fundacao Fac Reg Med FUNFARME

^[4] Fundacao Fac Reg Med FUNFARME

^[5] Fundacao Fac Reg Med FUNFARME

^[6] Fac Med Sao Jose do Rio Preto FAMERP. Dept Biol Mol

^[8] Fac Med Sao Jose do Rio Preto FAMERP. Dept Biol Mol

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF IMMUNOGENETICS; v. 42, n. 1, p. 19-25, FEB 2015.
• Citações Web of Science: 4

Resumo

The aim of this study was to estimate the HLA-A, HLA-B and HLA-DRB1 allele groups frequencies in a population of 1559 volunteer bone marrow donors from the northwestern region of SAo Paulo State grouped according to ethnicity. An additional objective was to compare the allele frequencies of the current study with data published for other Brazilian populations. The allele groups were characterized by the PCR-rSSO method using Luminex((R)) technology. Twenty HLA-A, 32 HLA-B and 13 HLA-DRB1 allele groups were identified. The most common allele groups in European descent and mixed African and European descent samples were HLA-A{*}02, HLA-B{*}35 and HLA-DRB1{*}13, while HLA-A{*}02, HLA-B{*}35 and HLA-DRB1{*}11 were more common in African descent samples. The HLA-A{*}23, HLA-A{*}36, HLA-B{*}58 and HLA-B{*}81 allele groups were more common in sample from African descent than European descent, and the HLA-DRB1{*}08 was more common in mixed African and European descent than in European descent. Allele group frequencies were compared with samples from other Brazilian regions. The HLA-A{*}30 and HLA-A{*}23 were more common in this study than in the populations of Rio Grande do Sul and Parana; and the HLA-A{*}01, HLA-B{*}18, HLA-B{*}57 and HLA-DRB1{*}11 were more common in this study than in the population of Piaui. The least frequent allele groups were HLA-A{*}31, HLA-B{*}15, HLA-B{*}40 and HLA-DRB1{*}08 for the population of Piaui, HLA-A{*}01 and HLA-A{*}11 for Parana, HLA-A{*}02 and -A{*}03 for Rio Grande do Sul and HLA-DRB1{*}04 for Parana, Rio Grande do Sul and Piaui. These data provide an overview on the knowledge on HLA diversity in the population of the northwestern region of SAo Paulo State and show that the genes of this system are useful to distinguish different ethnic groups. (AU)

• Processo FAPESP: 12/20735-2 - Marcadores imunogenéticos relacionados à doença de Chagas
• Beneficiário: Ana Vitória da Silveira Camargo
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 13/25650-8 - Genes HLA de classe II (DRB1 e DQB1) como fatores de risco para a toxoplasmose ocular
• Beneficiário: Luiz Carlos de Mattos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/06580-9 - Genes KIR, seus ligantes HLA e polimorfismo do gene MICA na toxoplasmose ocular e na forma digestiva da doença de Chagas
• Beneficiário: Christiane Maria Ayo
• Modalidade de apoio: Bolsas no Brasil - Doutorado