Pamidronate Attenuates Diastolic Dysfunction Induced by Myocardial Infarction Associated with Changes in Geometric Patterning

Autor(es):Mostrar menos -

Goncalves, Andrea F. ^[1] ; Congio, Luiz Henrique ^[1] ; dos Santos, Priscila P. ^[1] ; Rafacho, Bruna P. M. ^[1] ; Pereira, Bruna L. B. ^[1] ; Claro, Renan F. T. ^[1] ; Costa, Nara A. ^[1] ; Chiuso-Minicucci, Fernanda ^[2] ; Azevedo, Paula S. ^[1] ; Polegato, Bertha F. ^[1] ; Okoshi, Katashi ^[1] ; Pereira, Elenize J. ^[1] ; Okoshi, Marina P. ^[1] ; Paiva, Sergio A. R. ^[1] ; Zornoff, Leonardo A. M. ^[1] ; Minicucci, Marcos F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Botucatu Med Sch, Internal Med Dept, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Dept Microbiol & Immunol, Inst Biosci, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 35, n. 1, p. 259-269, 2015.
• Citações Web of Science: 5

Resumo

Background/Aims: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Methods: Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Results: Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins. Conclusion: Pamidronate attenuates diastolic dysfunction following MI. Copyright (C) 2015 S. Karger AG, Basel (AU)

• Processo FAPESP: 11/10328-8 - Influência do pamidronato na remodelação cardíaca após o infarto agudo do miocárdio
• Beneficiário: Luiz Henrique Congio
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica