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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pamidronate Attenuates Diastolic Dysfunction Induced by Myocardial Infarction Associated with Changes in Geometric Patterning

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Author(s):
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Goncalves, Andrea F. [1] ; Congio, Luiz Henrique [1] ; dos Santos, Priscila P. [1] ; Rafacho, Bruna P. M. [1] ; Pereira, Bruna L. B. [1] ; Claro, Renan F. T. [1] ; Costa, Nara A. [1] ; Chiuso-Minicucci, Fernanda [2] ; Azevedo, Paula S. [1] ; Polegato, Bertha F. [1] ; Okoshi, Katashi [1] ; Pereira, Elenize J. [1] ; Okoshi, Marina P. [1] ; Paiva, Sergio A. R. [1] ; Zornoff, Leonardo A. M. [1] ; Minicucci, Marcos F. [1]
Total Authors: 16
Affiliation:
[1] Univ Estadual Paulista UNESP, Botucatu Med Sch, Internal Med Dept, Botucatu, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Microbiol & Immunol, Inst Biosci, Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 35, n. 1, p. 259-269, 2015.
Web of Science Citations: 5
Abstract

Background/Aims: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Methods: Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Results: Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins. Conclusion: Pamidronate attenuates diastolic dysfunction following MI. Copyright (C) 2015 S. Karger AG, Basel (AU)

FAPESP's process: 11/10328-8 - Influence of pamidronate on cardiac remodeling after miocardial infarction in rats
Grantee:Luiz Henrique Congio
Support Opportunities: Scholarships in Brazil - Scientific Initiation