Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Autor(es)

Bueno, Valquiria ^[1] ; Sant'Anna, Osvaldo Augusto ^[2] ; Lord, Janet M. ^[3]

Afiliação do(s) autor(es)

^[1] UNIFESP Fed Univ Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil

^[2] Butantan Inst, Lab Immunochem, Sao Paulo - Brazil

^[3] Univ Birmingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Sch Immun & Infect, Birmingham, W Midlands - England

• Tipo de documento: Artigo Científico
• Fonte: AGE; v. 36, n. 6 DEC 2014.
• Citações Web of Science: 30

Resumo

Infections, cancer and autoimmune diseases occur more frequently in the elderly, and although many factors contribute to this, the age-related remodelling of the immune system, termed immunosenescence, plays a major role. Over the last two decades, studies have evaluated the effect of ageing on both the adaptive and innate arms of the immune system and demonstrated compromised function in several cells including lymphocytes (naive, effector and memory), regulatory T and B cells, monocytes, neutrophils and NK cells. In addition, a well-documented feature of ageing is the increase in systemic inflammatory status (inflammageing), with raised serum levels of IL6, TNF alpha and CRP as well as reduced IL10. Recently, myeloid-derived suppressor cells have been the focus of many reports as these cells show immunosuppressive properties and are present in higher frequency during infections, cancer and autoimmunity. Importantly, there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans. In this review, we discuss the current literature on myeloid-derived suppressor cells, their possible role in altered immune function in the elderly, and whether it may be possible to manipulate these cells to alleviate age-related immune dysfunction. (AU)

• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 12/51747-6 - Análise imunológica de indivíduos idosos e propostas em vacinação
• Beneficiário: Valquiria Bueno
• Modalidade de apoio: Auxílio à Pesquisa - Regular