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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic infl ammatory activity

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Autor(es):
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Virginio, V. W. M. [1, 2, 3] ; Nunes, V. S. [4] ; Moura, F. A. [1] ; Menezes, F. H. [5] ; Andreollo, N. A. [5] ; Rogerio, F. [6] ; Scherrer, D. Z. [2, 3] ; Quintao, E. C. R. [4] ; Nakandakare, E. [4] ; Petrucci, O. [5] ; Nadruz-Junior, W. [1] ; de Faria, E. C. [2, 3] ; Sposito, A. C.
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Med Sci, Dept Cardiol, UNICAMP, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Lipid Lab, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Ctr Med & Expt Surg, Campinas, SP - Brazil
[4] Univ Sao Paulo, Fac Med Sci, Lipids Lab LIM 10, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Fac Med Sci, UNICAMP, Dept Surg, Campinas, SP - Brazil
[6] Univ Estadual Campinas, Fac Med Sci, UNICAMP, Dept Pathol, Campinas, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Free Radical Research; v. 49, n. 2, p. 199-203, FEB 2015.
Citações Web of Science: 14
Resumo

Introduction. Cholesterol undergoes oxidation via both enzymatic stress-and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, enzymatic stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease in humans. Methods. 24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54 -84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45 - 78 years, controls). Results. Plasma 25-HC was higher in PAD individuals than in controls (6.3{[}2] vs. 3.9{[}1.9] ng/mgCol; p = 0.004). 24S-HC and 27-HC levels were, respectively, five-and 20-fold higher in the arterial tissue of PAD individuals than in those of the controls (p = 0.016 and p = 0.001). Plasma C-reactive protein correlated with plasma 24-HC (r = 0.51; p = 0.010), 25-HC (r = 0.75; p < 0.001), 27-HC (r = 0.48; p = 0.015), and with tissue 24S-HC (r = 0.4; p = 0.041) and 27-HC (r = 0.46; p = 0.023). Conclusion. Arterial intima accumulation of 27-HC and 24S-HC is associated with advanced atherosclerotic disease and systemic inflammatory activity in individuals with severe PAD. (AU)

Processo FAPESP: 06/60585-9 - Relação da concentração de HDL colesterol no plasma com o metabolismo corpóreo de colesterol e em monócitos no ser humano
Beneficiário:Eder Carlos Rocha Quintão
Linha de fomento: Auxílio à Pesquisa - Temático