| Full text | |
| Author(s): Show less - |
Virginio, V. W. M.
[1, 2, 3]
;
Nunes, V. S.
[4]
;
Moura, F. A.
[1]
;
Menezes, F. H.
[5]
;
Andreollo, N. A.
[5]
;
Rogerio, F.
[6]
;
Scherrer, D. Z.
[2, 3]
;
Quintao, E. C. R.
[4]
;
Nakandakare, E.
[4]
;
Petrucci, O.
[5]
;
Nadruz-Junior, W.
[1]
;
de Faria, E. C.
[2, 3]
;
Sposito, A. C.
Total Authors: 13
|
| Affiliation: | [1] Univ Estadual Campinas, Fac Med Sci, Dept Cardiol, UNICAMP, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Lipid Lab, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Ctr Med & Expt Surg, Campinas, SP - Brazil
[4] Univ Sao Paulo, Fac Med Sci, Lipids Lab LIM 10, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Fac Med Sci, UNICAMP, Dept Surg, Campinas, SP - Brazil
[6] Univ Estadual Campinas, Fac Med Sci, UNICAMP, Dept Pathol, Campinas, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Free Radical Research; v. 49, n. 2, p. 199-203, FEB 2015. |
| Web of Science Citations: | 14 |
| Abstract | |
Introduction. Cholesterol undergoes oxidation via both enzymatic stress-and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, enzymatic stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease in humans. Methods. 24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54 -84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45 - 78 years, controls). Results. Plasma 25-HC was higher in PAD individuals than in controls (6.3{[}2] vs. 3.9{[}1.9] ng/mgCol; p = 0.004). 24S-HC and 27-HC levels were, respectively, five-and 20-fold higher in the arterial tissue of PAD individuals than in those of the controls (p = 0.016 and p = 0.001). Plasma C-reactive protein correlated with plasma 24-HC (r = 0.51; p = 0.010), 25-HC (r = 0.75; p < 0.001), 27-HC (r = 0.48; p = 0.015), and with tissue 24S-HC (r = 0.4; p = 0.041) and 27-HC (r = 0.46; p = 0.023). Conclusion. Arterial intima accumulation of 27-HC and 24S-HC is associated with advanced atherosclerotic disease and systemic inflammatory activity in individuals with severe PAD. (AU) | |
| FAPESP's process: | 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters |
| Grantee: | Eder Carlos Rocha Quintão |
| Support Opportunities: | Research Projects - Thematic Grants |