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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic infl ammatory activity

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Author(s):
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Virginio, V. W. M. [1, 2, 3] ; Nunes, V. S. [4] ; Moura, F. A. [1] ; Menezes, F. H. [5] ; Andreollo, N. A. [5] ; Rogerio, F. [6] ; Scherrer, D. Z. [2, 3] ; Quintao, E. C. R. [4] ; Nakandakare, E. [4] ; Petrucci, O. [5] ; Nadruz-Junior, W. [1] ; de Faria, E. C. [2, 3] ; Sposito, A. C.
Total Authors: 13
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Dept Cardiol, UNICAMP, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Lipid Lab, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Ctr Med & Expt Surg, Campinas, SP - Brazil
[4] Univ Sao Paulo, Fac Med Sci, Lipids Lab LIM 10, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Fac Med Sci, UNICAMP, Dept Surg, Campinas, SP - Brazil
[6] Univ Estadual Campinas, Fac Med Sci, UNICAMP, Dept Pathol, Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Free Radical Research; v. 49, n. 2, p. 199-203, FEB 2015.
Web of Science Citations: 14
Abstract

Introduction. Cholesterol undergoes oxidation via both enzymatic stress-and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, enzymatic stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease in humans. Methods. 24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54 -84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45 - 78 years, controls). Results. Plasma 25-HC was higher in PAD individuals than in controls (6.3{[}2] vs. 3.9{[}1.9] ng/mgCol; p = 0.004). 24S-HC and 27-HC levels were, respectively, five-and 20-fold higher in the arterial tissue of PAD individuals than in those of the controls (p = 0.016 and p = 0.001). Plasma C-reactive protein correlated with plasma 24-HC (r = 0.51; p = 0.010), 25-HC (r = 0.75; p < 0.001), 27-HC (r = 0.48; p = 0.015), and with tissue 24S-HC (r = 0.4; p = 0.041) and 27-HC (r = 0.46; p = 0.023). Conclusion. Arterial intima accumulation of 27-HC and 24S-HC is associated with advanced atherosclerotic disease and systemic inflammatory activity in individuals with severe PAD. (AU)

FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
Grantee:Eder Carlos Rocha Quintão
Support type: Research Projects - Thematic Grants