Cannabinoid CBI receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence

Autor(es)

Lisboa, Sabrina F. ^{[1, 2]} ; Borges, Anna A. ^{[1, 2]} ; Nejo, Priscila ^[2] ; Fassini, Aline ^[2] ; Guimaraes, Francisco S. ^{[1, 2]} ; Resstel, Leonardo B. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo FMRP USP, Med Sch Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 59, p. 76-83, JUN 3 2015.
• Citações Web of Science: 10

Resumo

Endocannabinoids (ECBs) such as anandamide (AEA) act by activating cannabinoid type 1 (CI31) or 2 (CB2) receplors. The anxiolylic effect of drugs Lha L ECB effecis is associaled with increase in AEA levels in several encephalic areas, including Lhe prefrontal corlex Activalion of CBI receplors by 031 agonists injecled direcily into these areas is usually anxiolylic. However, depending on the encephalic region being investigated and on the slressful experiences, opposite effects were observed, as reported in the verthal HIP. In addilion, contradictory resulls have been reported after CBI activation in Lhe dorsal HIP (dHIP).Therefore, in the preseth paper WC have allempled Lo verify if directly iffierfering with ECB melabolism/reuplake in the prelimbic (PL) portion of the medial PlC (MPFC) and dHIP would produce different effects in Lwo conceptually dislincl animal models: the elevaled plus maze ({[}PM) and Lhe Vogel conflict Lest (VCT). We observed that drugs which interfere with ECB reuptakeimetabolism in both the PL and in the dentate gyrus of the dHIP induced anxiolytic-like effect, in both the EPM and in the VCT via CB1 receptors, suggesting that CBI signaling in these brain regions modulates defensive responses to both innate and learned threatening stimuli. This data further strengthens previous results indicating modulation of hippocampal and MPFC activity via CB1 by ECBs, which could be therapeutically targeted to treat anxiety disorders. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos
• Beneficiário: Francisco Silveira Guimaraes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/06999-9 - Estudo da possível interação entre os sistemas canabinóide e nitrérgico na substância cinzenta periaquedutal dorsolateral na modulação de comportamentos defensivos em ratos
• Beneficiário: Sabrina Francesca de Souza Lisboa
• Modalidade de apoio: Bolsas no Brasil - Doutorado