Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A framework for analyzing the relationship between gene expression and morphological, topological, and dynamical patterns in neuronal networks

Texto completo
Autor(es):
de Arruda, Henrique Ferraz [1] ; Comin, Cesar Henrique [2] ; Miazaki, Mauro [3] ; Viana, Matheus Palhares [2] ; Costa, Luciano da Fontoura [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Math & Comp Sci Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Phys Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[3] Midwestern State Univ, Dept Comp Sci, Guarapuava, PR - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF NEUROSCIENCE METHODS; v. 245, p. 1-14, APR 30 2015.
Citações Web of Science: 2
Resumo

Background: A key point in developmental biology is to understand how gene expression influences the morphological and dynamical patterns that are observed in living beings. New method: In this work we propose a methodology capable of addressing this problem that is based on estimating the mutual information and Pearson correlation between the intensity of gene expression and measurements of several morphological properties of the cells. A similar approach is applied in order to identify effects of gene expression over the system dynamics. Neuronal networks were artificially grown over a lattice by considering a reference model used to generate artificial neurons. The input parameters of the artificial neurons were determined according to two distinct patterns of gene expression and the dynamical response was assessed by considering the integrate-and-fire model. Results: As far as single gene dependence is concerned, we found that the interaction between the gene expression and the network topology, as well as between the former and the dynamics response, is strongly affected by the gene expression pattern. In addition, we observed a high correlation between the gene expression and some topological measurements of the neuronal network for particular patterns of gene expression. Comparison with existing methods: To our best understanding, there are no similar analyses to compare with. Conclusions: A proper understanding of gene expression influence requires jointly studying the morphology, topology, and dynamics of neurons. The proposed framework represents a first step towards predicting gene expression patterns from morphology and connectivity. (C) 2015 Published by Elsevier B.V. (AU)

Processo FAPESP: 07/50988-1 - Estudo da forma, função e expressão gênica em neurociência
Beneficiário:Mauro Miazaki
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/22639-8 - Estudo da relação estrutura-dinâmica em redes modulares
Beneficiário:Cesar Henrique Comin
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/50761-2 - Modelos e métodos de e-Science para ciências da vida e agrárias
Beneficiário:Roberto Marcondes Cesar Junior
Linha de fomento: Auxílio à Pesquisa - Temático