Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Autor(es)

Ono, E. ^[1] ; dos Santos, A. M. ^[2] ; Viana, P. O. ^[1] ; Dinelli, M. I. S. ^[1] ; Sass, N. ^[3] ; De Oliveira, L. ^[3] ; Goulart, A. L. ^[2] ; de Moraes-Pinto, M. I. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Pediat, Div Neonatal Med, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF TRANSPLANTATION; v. 15, n. 6, p. 1654-1665, JUN 2015.
• Citações Web of Science: 9

Resumo

Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, T cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age. At birth, infants born to female kidney recipients showed lower numbers of CD4+ T, NKT and intense reduction of B cells (median cells/mm(3), transplant: 153.7 X control: 512.4; p<0.001). There was also a reduced percentage of activated CD8+ T and of CD4+ regulatory T cells. Activated memory and exhausted memory B cells showed higher percentages among children exposed to immunosuppressors when compared to control group. At 8 months, most immune alterations were no longer observed, but four children still had low numbers of some lymphocyte subsets at this age. Children born to female kidney recipients had 4.351 (95% CI: 1.026-15.225; p=0.046) higher risk of hospital admission in the first months of lifesome, with severe clinical manifestationsthan those born to healthy women. (AU)

• Processo FAPESP: 08/06232-2 - O sistema imune em crianças nascidas de mulheres submetidas a transplante renal: avaliação fenotípica e funcional ao nascimento e no segundo semestre de vida.
• Beneficiário: Erika Ono Kawaoku
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 01/11011-6 - Subpopulações de células monomorfonucleares periféricas do nascimento aos 18 anos: valores na população sadia e infectada pelo HIV-1
• Beneficiário: Maria Isabel de Moraes Pinto
• Modalidade de apoio: Auxílio à Pesquisa - Regular