Pilot-scale synthesis and rheological assessment of poly(methyl methacrylate) polymers: Perspectives for medical application

Autor(es)

Linan, Lamia Zuniga ^[1] ; Nascimento Lima, Nadson M. ^[1] ; Maciel Filho, Rubens ^[1] ; Sabino, Marcos A. ^[2] ; Kozlowski, Mark T. ^[3] ; Manenti, Flavio ^[4]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Sch Chem Engn, BR-13083852 Campinas, SP - Brazil

^[2] Univ Simon Bolivar, Dept Quim, Grp B5IDA, Caracas 1080A - Venezuela

^[3] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 - USA

^[4] Politecn Milan, Dipartamento Chim Mat & Ingn Chim, I-20133 Milan - Italy

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 51, p. 107-116, JUN 1 2015.
• Citações Web of Science: 3

Resumo

This work presents the rheological assessment of poly(methyl methacrylate) (PMMA) polymers synthesized in a dedicated pilot-scale plant. This material is to be used for the construction of scaffolds via Rapid Prototyping (RP). The polymers were prepared to match the physical and biological properties required for medical applications. Differential Scanning Calorimetry (DSC) and Size Exclusion Chromatography (SEC) measurements verified that the synthesized polymers were atactic, amorphous and linear in chains. Rheological properties such as viscosity, storage and loss modulus, beyond the loss factor, and creep and recovery were measured in a plate-plate sensor within the viscoelastic linear region. The results showed the relevant influence of the molecular weight on the viscosity and elasticity of the material, and how, as the molecular weight increases, the viscoelastic properties are getting closer to those of human bone. This article demonstrates that by using the implemented methodology it is possible to synthesize a polymer, with properties comparable to commercially-available PMMA. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/09631-8 - Estudo e modelagem do processo de produção do polimetilmetacrilato para a fabricação de tecido ósseo artificial
• Beneficiário: Rubens Maciel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/16952-2 - Modelagem e controle ótimo por lógica fuzzy de processos de produção de biomateriais
• Beneficiário: Nádson Murilo Nascimento Lima
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/57860-3 - BIOFABRIS - Instituto de Biofabricação
• Beneficiário: Rubens Maciel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 09/09092-0 - Estudo e modelagem do processo de produção do polimetilmetacrilato para a fabricação de tecido ósseo artificial
• Beneficiário: Lamia Zuniga Linan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado