Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats

Autor(es)

Fratucci De Gobbi, Juliana Irani ^[1] ; Mieko Omoto, Ana Carolina ^[1] ; Siqueira, Tamires Ferreira ^[1] ; Matsubara, Luiz Shigueto ^[2] ; Roscani, Meliza Goi ^[2] ; Matsubara, Beatriz Bojikian ^[2]

Afiliação do(s) autor(es)

^[1] UNESP Botucatu, Inst Biosci, Dept Physiol, Botucatu, SP - Brazil

^[2] UNESP, Botucatu Med Sch, Dept Internal Med, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Physiology & Behavior; v. 144, p. 124-128, MAY 15 2015.
• Citações Web of Science: 1

Resumo

Depression is a predictor of poor prognosis in patients with heart failure. Selective serotonin (5-HT) reuptake inhibitors (SSR1s) may improve these outcomes. Left ventricular volume overload induced hypertrophy that is associated with aortic regurgitation (AR) leads to ventricular dysfunction and heart failure. The aim of this study was to verify the effects of the SSRI paroxetine on cardiac function, as well as on fluid intake and excretion, in subchronic AR. Male Wistar rats (260 to 280 g) received sham (SH) surgery or AR induced by retrograde puncture of the aortic valve leaflets. The presence of AR was confirmed by echocardiography (ECHO) exams. Four weeks after AR surgery, subcutaneous injections of paroxetine (PAR: 10 mg/kg 3 times in a week) or saline were administered. The rats were randomly divided into the following 4 groups and treated for 4 weeks: AR-PAR, ARsaline, SH-PAR and SH-saline. At the end of the treatment period, fractional shortening was preserved in AR-PAR, compared to AR-saline (46.6 +/- 2.7% vs 38.3 +/- 2.2%, respectively). Daily 0.3 M NaCl intake was reduced in PAR-treated rats. Natriuresis was increased in weeks 2-3 after PAR treatment. Our results suggest that augmentation of central 5-HT neurotransmission has a beneficial effect on cardiovascular remodeling following volume overload. The mechanisms underlying this effect are Unknown. (C) 2015 The Authors. Published by Elsevier Inc This is an open access article under the CC BY-NC-ND license (AU)

• Processo FAPESP: 09/51222-8 - Evolução das modificações morfo-funcionais cardíacas no processo de adaptação crônica a insuficiência aórtica aguda experimental em ratos
• Beneficiário: Beatriz Bojikian Matsubara
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/17575-0 - Tratamento com antidepressivo em ratos com insuficiência aórtica subcrônica: atividade barorreflexa e excreção de sódio
• Beneficiário: Tamires Ferreira Siqueira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/52547-8 - Insuficiencia cardiaca e vias centrais relacionadas a regulacao do volume plasmatico
• Beneficiário: Juliana Irani Fratucci de Gobbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular