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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

T-3 rapidly regulates several steps of alpha subunit glycoprotein (CGA) synthesis and secretion in the pituitary of male rats: Potential repercussions on TSH, FSH and LH secretion

Texto completo
Autor(es):
Bargi-Souza, Paula [1] ; Romano, Renata Marino [1] ; Goulart-Silva, Francemilson [1] ; Brunetto, Erika Lia [1] ; Nunes, Maria Tereza [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Molecular and Cellular Endocrinology; v. 409, n. C, p. 73-81, JUL 5 2015.
Citações Web of Science: 11
Resumo

TSH, FSH and LH share the same glycoprotein alpha chain (CGA) as part of their protein structure. Therefore, it is possible that thyroid and gonadal dysfunction may affect the CGA expression. This study evaluated several steps of CGA synthesis and secretion in thyrotrophs and gonadotrophs of control and hypothyroid rats, acutely or chronically-treated with T-3. Hypothyroidism increased the Cga mRNA expression and its association to ribosome, but decreased intracellular CGA content. These parameters were reversed after acute or chronic T-3 treatment. We conclude that T-3 not only down-regulates Cga mRNA expression, as expected, but also inhibits the association of Cga mRNA to ribosome, as well as the CGA secretion. These findings add novel insights into our understanding of the role of T-3 on the regulation of the Cga gene expression and CGA secretion, which might have a potential repercussion in all pituitary glycoprotein hormone synthesis and secretion. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 08/50977-2 - Influencia do hormonio tiroideano na atividade do gonadotrofo.
Beneficiário:Renata Marino Romano
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 06/61713-0 - Acoes nao genomicas dos hormonios tireoideanos na hipofise de ratos: repercussoes na sintese e secrecao de hormonio do crescimento (gh) e tireotrofico (tsh).
Beneficiário:Maria Tereza Nunes
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 07/56631-8 - Efeito da administracao aguda de triiodotironina (t3) sobre a regulacao pos-transcricional da expressao genica do hormonio tireotrofico (beta-tsh).
Beneficiário:Paula Bargi de Souza
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 06/59863-4 - Acao nao genomica dos hormonios tireoideanos sobre o musculo cardiaco: repercusoes sobre o metabolismo energetico.
Beneficiário:Erika Lia Brunetto Ract
Linha de fomento: Bolsas no Brasil - Doutorado