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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neuronal STAT5 signaling is required for maintaining lactation but not for postpartum maternal behaviors in mice

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Autor(es):
Buonfiglio, Daniella C. [1] ; Ramos-Lobo, Angela M. [1] ; Silveira, Marina A. [2] ; Furigo, Isadora C. [1] ; Hennighausen, Lothar [3] ; Frazao, Renata [2] ; Donato, Jr., Jose [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, BR-05508900 Sao Paulo, SP - Brazil
[3] NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Hormones and Behavior; v. 71, p. 60-68, MAY 2015.
Citações Web of Science: 12
Resumo

Prolactin and placental lactogens control mammary development and lactation as well as play an important role in maternal behaviors. However, the molecular mechanisms in the brain responsible for this regulation remain largely unknown. Therefore, the present study investigated whether Signal Transducer and Activator of Transcription 5 (STAT5) signaling in the brain, the key transcriptional factor recruited by prolactin receptor and other hormones, is required for postpartum maternal behavior, maintenance of lactation and offspring growth. Neuronal ablation of STAT5 impaired the control of prolactin secretion and reduced the hypothalamic expression of suppressors of cytokine signaling (i.e., SOCS3 and CISH). In addition, neuronal STAT5 deletion attenuated the hyperphagia commonly observed during lactation by decreasing the hypothalamic expression of orexigenic neurotransmitters such as the neuropeptide Y and agouti-related protein. The lower food intake of lactating neuron-specific STAT5 knockout females resulted in reduced milk production and offspring growth. Unexpectedly, postpartum maternal behavior expression was not impaired in neuron-specific STAT5 knockout females. On the contrary, the latency to retrieve and group the pups into the nest was reduced in mutant dams. Finally, we demonstrated that approximately 30% of recorded neurons in the medial preoptic area were acutely depolarized by prolactin suggesting that fast STAT5-independent signaling pathways may be involved in the regulation of maternal behaviors. Overall, our results revealed important information about the molecular mechanisms recruited by hormones to orchestrate the activation of neural circuitries engaged in the induction of maternal care. (C) 2015 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 12/12202-4 - Modulação das propriedades biofísicas de neurônios Kiss1 por fatores circadianos
Beneficiário:Renata Frazão
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/21722-4 - Estudo do mecanismo de ação da Bromocriptina e de antagonistas de prolactina no tratamento do Diabetes Mellitus tipo 2 e da Obesidade.
Beneficiário:Isadora Clivatti Furigo
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/11752-6 - Estudo das funções da leptina durante o período intrauterino e infância no camundongo
Beneficiário:Angela Maria Ramos Lobo
Modalidade de apoio: Bolsas no Brasil - Doutorado