Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes

Autor(es)

da Silva Pellegrina, Diogo Vieira ^[1] ; Severino, Patricia ^[2] ; Barbeiro, Hermes Vieira ^[3] ; Andreghetto, Flavia Maziero ^[2] ; Velasco, Irineu Tadeu ^[3] ; de Souza, Heraldo Possolo ^[3] ; Cesar Machado, Marcel Cerqueira ^[3] ; Reis, Eduardo Moraes ^[4] ; da Silva, Fabiano Pinheiro ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Programa Interunidades Posgrad Bioinformat, Sao Paulo - Brazil

^[2] Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Dept Emergencias Clin, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 10, n. 6 JUN 5 2015.
• Citações Web of Science: 10

Resumo

Sepsis is one of the highest causes of mortality in hospitalized people and a common complication in both surgical and clinical patients admitted to hospital for non-infectious reasons. Sepsis is especially common in older people and its incidence is likely to increase substantially as a population ages. Despite its increased prevalence and mortality in older people, immune responses in the elderly during septic shock appear similar to that in younger patients. The purpose of this study was to conduct a genome-wide gene expression analysis of circulating neutrophils from old and young septic patients to better understand how aged individuals respond to severe infectious insult. We detected several genes whose expression could be used to differentiate immune responses of the elderly from those of young people, including genes related to oxidative phosphorylation, mitochondrial dysfunction and TGF-a signaling, among others. Our results identify major molecular pathways that are particularly affected in the elderly during sepsis, which might have a pivotal role in worsening clinical outcomes compared with young people with sepsis. (AU)

• Processo FAPESP: 12/03677-9 - A imunidade inata no indivíduo idoso: fatores predisponentes para sepse e outras doenças complexas
• Beneficiário: Marcel Cerqueira Cesar Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/03150-6 - Análise global da expressão de mRNAs e RNAs não codificadores no sistema imunológico humano na senescência e sepse
• Beneficiário: Diogo Vieira da Silva Pellegrina
• Modalidade de apoio: Bolsas no Brasil - Mestrado