Synthesis and applications of 4-substituted 1-(4-iodophenyl)pyrrolidine-2,5-diones

Autor(es)

Ali, Bakhat ^[1] ; Shamim, Anwar ^[2] ; Vasconcelos, Stanley N. S. ^[1] ; Stefani, Helio A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Tetrahedron Letters; v. 56, n. 28, p. 4234-4241, JUL 8 2015.
• Citações Web of Science: 1

Resumo

The synthesis of 4-substituted 1-(4-iodophenyl)pyrrolidine-2,5-dione derivatives was achieved through an addition reaction between amines and a thiol in the presence of PMDTA as a base and a copper salt. The derivatives containing a terminal acetylene moiety were converted to the corresponding 1,4-triazolyl derivatives. The 1-(4-iodophenyl)pyrrolidine-2,5-dione derivatives were functionalized through oxidation alkylation and allylation reactions. In general, the compounds were obtained in moderate-to-good yields. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/00424-2 - Síntese de pequenas bibliotecas empregando organotrifluoroboratos de potássio em reações de Suzuki-Miyaura
• Beneficiário: Helio Alexandre Stefani
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/17954-4 - Reações de Ciclização de Acetil- e Etoxil-pirrolidin-2-onas com Sais de Organotrifluoroboratos de Potássio
• Beneficiário: Bakhat Ali
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado