Disperse Red 1 (textile dye) induces cytotoxic and genotoxic effects in mouse germ cells

Autor(es)

Fernandes, Fabio Henrique ^[1] ; Bustos-Obregon, Eduardo ^[2] ; Favero Salvadori, Daisy Maria ^[3]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Biosci Inst, Dept Genet, BR-18618000 Botucatu, SP - Brazil

^[2] Univ Chile, Sch Med, Santiago - Chile

^[3] Univ Estadual Paulista, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 53, p. 75-81, JUN 2015.
• Citações Web of Science: 14

Resumo

Disperse Red 1 (DR1), which is widely used in the textile industry, is an azo dye that contributes to the toxicity and pollution of wastewater. To assess the toxic effects of DR1 on reproduction, sexually mature male mice (Mus musculus, strain CF-1) were orally (gavage) treated with single doses of the compound at 20, 100 and 500 mg/kg body weight. Testicular features and sperm parameters were evaluated 8.3, 16.6 and 24.9 days after treatments. In addition to testicular toxicity caused by the dye, the data clearly showed an increased frequency of sperm with abnormal morphology and decreased fertility. An increased amount of DNA damage was also detected in testis cells 16.6 and 24.9 days after treatments with 100 and 500 mg/kg. This study demonstrated the toxic and genotoxic effects of DR1, indicating the harmful activity of this dye on reproductive health. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 08/10449-7 - Avaliação da ocorrência, toxicidade/genotoxicidade e processos para degradação de corantes em efluentes e águas superficiais
• Beneficiário: Maria Valnice Boldrin
• Modalidade de apoio: Auxílio à Pesquisa - Temático