Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs

Autor(es)

Ribeiro, Marcelo Eduardo ^[1] ; Sequeira, Julio ^[2] ; Trinca, Luzia Aparecida ^[3] ; Yoshida, Winston Bonetti ^[4]

Afiliação do(s) autor(es)

^[1] Paulista State Univ UNESP, Botucatu Sch Med, Dept Surg & Orthoped, Postgrad Program Surg Gen Basis Surg, Botucatu, SP - Brazil

^[2] UNESP, Vet Med & Zootech Sch Med, Dept Pathol, Botucatu, SP - Brazil

^[3] UNESP, Biosci Inst, Dept Stat, Botucatu, SP - Brazil

^[4] UNESP, Dept Surg & Orthoped, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 30, n. 6, p. 407-413, JUN 2015.
• Citações Web of Science: 1

Resumo

PURPOSE:Vogt´s antioxidant solution (red blood cells, Ringer's solution, sodium bicarbonate, mannitol, allopurinol and 50% glucose) or its modification including hydroxyethyl starch (HES) were tested for the prevention of splanchnic artery occlusion shock.METHODS:Seventy rats were distributed in treatment (3), control (1), and sham (3) groups. Ischemia and reperfusion were induced by celiac, superior mesenteric and inferior mesenteric arteries occlusion for 40 min, followed by 60 min reperfusion or sham procedures. Controls received saline, both treatment and sham groups received the Vogt's solution, modified Vogt's solution (replacing Ringer's solution by HES), or HES. Mean arterial blood pressure (MABP), ileal malondialdehyde (MDA) and plasmatic MDA were determined, and a histologic grading system was used.RESULTS:At reperfusion, MABP dropped in all I/R groups. Only HES treatment was able to restore final MABP to the levels of sham groups. Plasmatic MDA did not show differences between groups. Ileum MDA was significantly higher in the control and treatment groups as compared to the sham group. Histology ranking was higher in the only in control group.CONCLUSIONS:Hydroxyethyl starch was able to prevent hemodynamic shock but not intestinal lesions. Both treatments with Vogt's solutions did not show any improvement. (AU)

• Processo FAPESP: 97/04647-4 - Estudo comparativo da acao de solucoes antioxidantes preservantes na atenuacao de alteracoes decorrentes de iquemia e reperfusao de orgaos esplancnicos - estudo experimental em ratos.
• Beneficiário: Winston Bonetti Yoshida
• Modalidade de apoio: Auxílio à Pesquisa - Regular