Genome-wide association with residual body weight gain in Bos indicus cattle

Autor(es):Mostrar menos -

Santana, M. H. A. ^[1] ; Gomes, R. C. ^[2] ; Utsunomiya, Y. T. ^[3] ; Neves, H. H. R. ^{[3, 4]} ; Novais, F. J. ^[1] ; Bonin, M. N. ^[2] ; Fukumasu, H. ^[1] ; Garcia, J. F. ^{[3, 5]} ; Alexandre, P. A. ^[1] ; Oliveira Junior, G. A. ^[1] ; Coutinho, L. L. ^[6] ; Ferraz, J. B. S. ^[1]

Afiliação do(s) autor(es)

^[1] Fac Zootecnia & Engn Alimentos, Pirassununga, SP - Brazil

^[2] Empresa Brasileira Pesquisa Agr, Campo Grande, MS - Brazil

^[3] Univ Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP - Brazil

^[4] GenSys Consultores Associados SC Ltda, Porto Alegre, RS - Brazil

^[5] Univ Estadual Paulista, Fac Med Vet Aracatuba, Aracatuba, SP - Brazil

^[6] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Piracicaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Genetics and Molecular Research; v. 14, n. 2, p. 5229-5233, 2015.
• Citações Web of Science: 2

Resumo

Weight gain is a key performance trait for beef cattle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on performance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and genomic regions associated with residual body weight gain (RWG), we conducted a genome-wide association study (GWAS) with 720 Nellore cattle using the GRAMMAR-Gamma association test. We identified 30 significant single nucleotide polymorphisms (SNPs), especially on chromosomes 2, 8, 12, and 17. Several genes and quantitative train loci (QTLs) present in the regions identified were appointed; we highlight DMRT2 (doublesex and mab-3 related transcription factor 2), IFFO2 (intermediate filament family orphan 2), LNX2 (ligand of numb-protein X 2), MTIF3 (mitochondrial translational initiation factor 3), and TRNAG-CCC (transfer RNA glycine anticodon CCC). The metabolic pathways that can explain part of the phenotypic variation in RWG are related to oxidative stress and muscle control. (AU)

• Processo FAPESP: 13/20571-2 - Genômica funcional da ingestão e eficiência alimentar de bovinos da raça Nelore
• Beneficiário: Miguel Henrique de Almeida Santana
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/02039-9 - Estudo genômico da ingestão e eficiência alimentar em bovinos da raça Nelore
• Beneficiário: José Bento Sterman Ferraz
• Modalidade de apoio: Auxílio à Pesquisa - Regular