| Full text | |
| Author(s): Show less - |
Santana, M. H. A.
[1]
;
Gomes, R. C.
[2]
;
Utsunomiya, Y. T.
[3]
;
Neves, H. H. R.
[3, 4]
;
Novais, F. J.
[1]
;
Bonin, M. N.
[2]
;
Fukumasu, H.
[1]
;
Garcia, J. F.
[3, 5]
;
Alexandre, P. A.
[1]
;
Oliveira Junior, G. A.
[1]
;
Coutinho, L. L.
[6]
;
Ferraz, J. B. S.
[1]
Total Authors: 12
|
| Affiliation: | [1] Fac Zootecnia & Engn Alimentos, Pirassununga, SP - Brazil
[2] Empresa Brasileira Pesquisa Agr, Campo Grande, MS - Brazil
[3] Univ Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP - Brazil
[4] GenSys Consultores Associados SC Ltda, Porto Alegre, RS - Brazil
[5] Univ Estadual Paulista, Fac Med Vet Aracatuba, Aracatuba, SP - Brazil
[6] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Piracicaba, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Genetics and Molecular Research; v. 14, n. 2, p. 5229-5233, 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
Weight gain is a key performance trait for beef cattle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on performance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and genomic regions associated with residual body weight gain (RWG), we conducted a genome-wide association study (GWAS) with 720 Nellore cattle using the GRAMMAR-Gamma association test. We identified 30 significant single nucleotide polymorphisms (SNPs), especially on chromosomes 2, 8, 12, and 17. Several genes and quantitative train loci (QTLs) present in the regions identified were appointed; we highlight DMRT2 (doublesex and mab-3 related transcription factor 2), IFFO2 (intermediate filament family orphan 2), LNX2 (ligand of numb-protein X 2), MTIF3 (mitochondrial translational initiation factor 3), and TRNAG-CCC (transfer RNA glycine anticodon CCC). The metabolic pathways that can explain part of the phenotypic variation in RWG are related to oxidative stress and muscle control. (AU) | |
| FAPESP's process: | 13/20571-2 - Functional genomics of feed intake and efficiency in Nellore cattle |
| Grantee: | Miguel Henrique de Almeida Santana |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/02039-9 - Genomic study of feed intake and efficiency in Nellore cattle |
| Grantee: | José Bento Sterman Ferraz |
| Support Opportunities: | Regular Research Grants |