Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds

Autor(es):Mostrar menos -

Passalacqua, Thais Gaban ^{[1, 2]} ; Dutra, Luiz Antonio ^{[3, 4]} ; de Almeida, Leticia ^{[1, 2]} ; Arenas Velasquez, Angela Maria ^{[1, 2]} ; Esteves Torres, Fabio Aurelio ^{[1, 2]} ; Yamasaki, Paulo Renato ^[3] ; dos Santos, Mariana Bastos ^[5] ; Regasini, Luis Octavio ^[5] ; Michels, Paul A. M. ^[6] ; Bolzani, Vanderlan da Silva ^[1] ; Graminha, Marcia A. S. ^{[3, 2]}

Afiliação do(s) autor(es)

^[1] UNESP, Inst Quim, BR-14800060 Araraquara, SP - Brazil

^[2] Programa Posgrad Biotecnol, Florianopolis, SC - Brazil

^[3] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

^[4] Programa Pos Grad Ciencias Farmaceut, Florianopolis, SC - Brazil

^[5] Univ Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[6] Univ Edinburgh, Inst Struct & Mol Biol, Edinburgh EH8 9YL, Midlothian - Scotland

• Tipo de documento: Artigo Científico
• Fonte: Bioorganic & Medicinal Chemistry Letters; v. 25, n. 16, p. 3342-3345, AUG 15 2015.
• Citações Web of Science: 28

Resumo

Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/16732-2 - Busca de novos antígenos para o diagnóstico da leishmaniose visceral canina: caracterização das proteínas TR Lc06, Lc22, Lc24 e Lc36
• Beneficiário: Marcia Aparecida Silva Graminha
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/52327-5 - Prospecção de moléculas bioativas e estudo de variabilidade infra-específica em plantas e microorganismos endófitos do cerrado e caatinga: contribuição para o conhecimento e uso sustentável da biodiversidade brasileira
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular