Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula

Autor(es)

Garcia-Cordero, Indira ^[1] ; Sedeno, Lucas ^{[1, 2, 3]} ; Fraiman, Daniel ^{[3, 4]} ; Craiem, Damian ^{[3, 5]} ; Alethia de la Fuente, Laura ^[1] ; Salamone, Paula ^[1] ; Serrano, Cecilia ^[6] ; Sposato, Luciano ^[7] ; Manes, Facundo ^{[1, 2, 3, 8]} ; Ibanez, Agustin ^{[1, 2, 3, 8, 9]}

Afiliação do(s) autor(es)

^[1] Favaloro Univ, Inst Cognit Neurol INECO, Lab Expt Psychol & Neurosci LPEN, Buenos Aires, DF - Argentina

^[2] Diego Portales Univ, Fac Psychol, UDP INECO Fdn Core Neurosci UIFCoN, Santiago - Chile

^[3] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF - Argentina

^[4] Univ San Andres, Lab Invest Neurociencia, Buenos Aires, DF - Argentina

^[5] Univ Favaloro, Fac Ingn Ciencias Exactas & Nat, Buenos Aires, DF - Argentina

^[6] Memory & Balance Clin, Buenos Aires, DF - Argentina

^[7] Univ Western Ontario, Dept Clin Neurol Sci, London, ON - Canada

^[8] ACR Ctr Excellence Cognit & Its Disorders, Sydney, NSW - Australia

^[9] Univ Autonoma Caribe, Barranquilla - Colombia

• Tipo de documento: Artigo Científico
• Fonte: STROKE; v. 46, n. 9, p. 2673-2677, SEP 2015.
• Citações Web of Science: 21

Resumo

Background and Purpose-Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods-Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results-Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions-Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Jefferson Antonio Galves
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs