The use of resting-state functional connectivity MRI (fcMRI) in the evaluation of ...
| Full text | |
| Author(s): |
Garcia-Cordero, Indira
[1]
;
Sedeno, Lucas
[1, 2, 3]
;
Fraiman, Daniel
[3, 4]
;
Craiem, Damian
[3, 5]
;
Alethia de la Fuente, Laura
[1]
;
Salamone, Paula
[1]
;
Serrano, Cecilia
[6]
;
Sposato, Luciano
[7]
;
Manes, Facundo
[1, 2, 3, 8]
;
Ibanez, Agustin
[1, 2, 3, 8, 9]
Total Authors: 10
|
| Affiliation: | [1] Favaloro Univ, Inst Cognit Neurol INECO, Lab Expt Psychol & Neurosci LPEN, Buenos Aires, DF - Argentina
[2] Diego Portales Univ, Fac Psychol, UDP INECO Fdn Core Neurosci UIFCoN, Santiago - Chile
[3] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF - Argentina
[4] Univ San Andres, Lab Invest Neurociencia, Buenos Aires, DF - Argentina
[5] Univ Favaloro, Fac Ingn Ciencias Exactas & Nat, Buenos Aires, DF - Argentina
[6] Memory & Balance Clin, Buenos Aires, DF - Argentina
[7] Univ Western Ontario, Dept Clin Neurol Sci, London, ON - Canada
[8] ACR Ctr Excellence Cognit & Its Disorders, Sydney, NSW - Australia
[9] Univ Autonoma Caribe, Barranquilla - Colombia
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | STROKE; v. 46, n. 9, p. 2673-2677, SEP 2015. |
| Web of Science Citations: | 22 |
| Abstract | |
Background and Purpose-Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods-Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results-Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions-Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications. (AU) | |
| FAPESP's process: | 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat |
| Grantee: | Jefferson Antonio Galves |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |