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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula

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Garcia-Cordero, Indira [1] ; Sedeno, Lucas [1, 2, 3] ; Fraiman, Daniel [3, 4] ; Craiem, Damian [3, 5] ; Alethia de la Fuente, Laura [1] ; Salamone, Paula [1] ; Serrano, Cecilia [6] ; Sposato, Luciano [7] ; Manes, Facundo [1, 2, 3, 8] ; Ibanez, Agustin [1, 2, 3, 8, 9]
Total Authors: 10
[1] Favaloro Univ, Inst Cognit Neurol INECO, Lab Expt Psychol & Neurosci LPEN, Buenos Aires, DF - Argentina
[2] Diego Portales Univ, Fac Psychol, UDP INECO Fdn Core Neurosci UIFCoN, Santiago - Chile
[3] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF - Argentina
[4] Univ San Andres, Lab Invest Neurociencia, Buenos Aires, DF - Argentina
[5] Univ Favaloro, Fac Ingn Ciencias Exactas & Nat, Buenos Aires, DF - Argentina
[6] Memory & Balance Clin, Buenos Aires, DF - Argentina
[7] Univ Western Ontario, Dept Clin Neurol Sci, London, ON - Canada
[8] ACR Ctr Excellence Cognit & Its Disorders, Sydney, NSW - Australia
[9] Univ Autonoma Caribe, Barranquilla - Colombia
Total Affiliations: 9
Document type: Journal article
Source: STROKE; v. 46, n. 9, p. 2673-2677, SEP 2015.
Web of Science Citations: 22

Background and Purpose-Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods-Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results-Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions-Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications. (AU)

FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
Grantee:Jefferson Antonio Galves
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC