Effects of heat stress on peripheral T and B lymphocyte profiles and IgG and IgM serum levels in broiler chickens vaccinated for Newcastle disease virus

Autor(es)

Bueno Honda, Bruno Takashi ^[1] ; Calefi, Atilio Sersun ^[1] ; Costola-de-Souza, Carolina ^[1] ; Quinteiro-Filho, Wanderley Moreno ^[1] ; da Silva Fonseca, Juliana Garcia ^[1] ; de Paula, Viviane Ferraz ^[1] ; Palermo-Neto, Joao ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Neuroimmunomodulat Res Grp, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: POULTRY SCIENCE; v. 94, n. 10, p. 2375-2381, OCT 2015.
• Citações Web of Science: 13

Resumo

Multiple factors, such as environment, nutritional status, and disease, induce stress in animals during livestock production. It has been shown that poultry exposed to stressors for prolonged periods had decreases in their performance parameters, mortality and decreased host resistance to pathogenic agents. It seems that early age stress may have long-lasting impact and could possibly modify the expression of their genetic potential on growth performance and immunity. This study aimed to discuss the effects of early-age heat stress on the blood lymphocyte phenotypes (B and T lymphocytes) and plasma immunoglobulin levels (IgM and IgG) in chickens vaccinated against paramixovirus of the Newcastle (NC) disease (LaSota strain). For this purpose, 96 male chickens (Cobb) were divided into 4 groups: 1) control (C), 2) heat-stressed (HS), 3) control vaccinated (C/V), and 4) heat-stressed and Vaccinated (HS/V). The NC vaccine was administered twice on experimental day (ED) 7 and ED14, and the heat stress (38 +/- 1 degrees C) was applied from ED2 to ED6. The data showed that HS increased the corticosterone serum levels in the HS group compared with the control groups (C and C/V groups). At ED7, increased concentrations of IgM were observed in birds in the HS and HS/V groups compared with C and C/V animals; chickens from the HS/V group presented increased IgG levels compared with those in the birds of the C group. The heat stress shifted the immune cell profile from B-lymphocyte to a T-cytotoxic and T-helper lymphocyte profile, and this immune cell pattern persisted until the end of the study period. It was concluded that heat stress immunomodulated the immune function response of the chickens to the NC disease vaccine challenge. (AU)

• Processo FAPESP: 13/17408-2 - Avaliação dos efeitos do estresse por calor sobre a imunidade de frangos de corte em um modelo experimental de enterite necrótica aviária
• Beneficiário: Atilio Sersun Calefi
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/13736-5 - Efeitos do Lactobacillus salivarius sobre a imunidade e a microbiota intestinal de frangos de corte estressados por calor e infectados com Salmonella Enteritidis
• Beneficiário: Wanderley Moreno Quinteiro Filho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/51886-3 - Neuroimunomodulação: fármacos, estresse e citocinas nas relações entre os sistemas nervoso, endócrino e imune
• Beneficiário: João Palermo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático