Regulation of leukocyte tricarboxylic acid cycle in drug-naive Bipolar Disorder

Autor(es):Mostrar menos -

de Sousa, Rafael T. ^{[1, 2]} ; Streck, Emilio L. ^[3] ; Forlenza, Orestes V. ^[2] ; Brunoni, Andre R. ^[2] ; Zanetti, Marcus V. ^{[4, 2, 5]} ; Ferreira, Gabriela K. ^[3] ; Diniz, Breno S. ^{[6, 7]} ; Portela, Luis V. ^[8] ; Carvalho, Andre F. ^{[9, 10]} ; Zarate, Jr., Carlos A. ^[1] ; Gattaz, Wagner F. ^[2] ; Machado-Vieira, Rodrigo ^{[2, 5]}

Afiliação do(s) autor(es)

^[1] NIMH, ETPB, NIH, Bethesda, MD 20892 - USA

^[2] Univ Sao Paulo, Inst & Dept Psychiat, Lab Neurosci, BR-05508 Sao Paulo - Brazil

^[3] Univ Extremo Sul Catarinense, Lab Bioenerget, Programa Posgrad Ciencias Saude, Criciuma, SC - Brazil

^[4] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-05508 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept & Inst Psychiat, Lab Psychiat Neuroimaging, BR-05508 Sao Paulo - Brazil

^[6] Univ Fed Minas Gerais, Fac Med, Dept Mental Hlth, Belo Horizonte, MG - Brazil

^[7] Univ Fed Minas Gerais, Natl Inst Sci & Technol Mol Med, Belo Horizonte, MG - Brazil

^[8] Fed Univ Rio Grande Sul UFRGS, ICBS, Dept Biochem, Postgrad Program Biochem, Porto Alegre, RS - Brazil

^[9] Univ Fed Ceara, Dept Clin Med, Fac Med, Fortaleza, Ceara - Brazil

^[10] Univ Fed Ceara, Translat Psychiat Res Grp, Fortaleza, Ceara - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Neuroscience Letters; v. 605, p. 65-68, SEP 25 2015.
• Citações Web of Science: 4

Resumo

Several lines of evidence suggest a role for mitochondrial dysfunction in the pathophysiology of bipolar disorder (BD). The tricarboxylic acid cycle (TCA cycle) is fundamental for mitochondrial energy production and produces substrates used in oxidative phosphorylation by the mitochondrial electron transport chain. The activity of the key TCA cycle enzymes citrate synthase, malate dehydrogenase, and succinate dehydrogenase has never been evaluated in BD. In the present study, these enzymes were assayed from leukocytes of drug-naive BD patients in a major depressive episode (n = 18) and compared to 24 age-matched healthy controls. Drug-naive BD patients did not show differences in activities of citrate synthase (p = 0.79), malate dehydrogenase (p = 0.17), and succinate dehydrogenase (p = 0.35) compared with healthy controls. No correlation between any TCA cycle enzyme activity and severity of depressive symptoms was observed. Overall, these data suggest that the activities of the TCA cycle enzymes are not altered in major depressive episodes of recent-onset BD, which may support the concept of illness staging and neuroprogression in BD. Published by Elsevier Ireland Ltd. (AU)

• Processo FAPESP: 09/14891-9 - Avaliação longitudinal dos efeitos neuroprotetores e neurotróficos induzidos pelo lítio no transtorno bipolar: identificação de alvos clinicamente relevantes
• Beneficiário: Rodrigo Machado-Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores