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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prospecting major genes in dairy buffaloes

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Autor(es):
de Camargo, G. M. F. [1] ; Aspilcueta-Borquis, R. R. [1] ; Fortes, M. R. S. [2] ; Porto-Neto, R. [3] ; Cardoso, D. F. [1] ; Santos, D. J. A. [1] ; Lehnert, S. A. [3] ; Reverter, A. [3] ; Moore, S. S. [4] ; Tonhati, H. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Fac Ciencias Agr & Vet, Dept Zootecnia, BR-14884900 Jaboticabal, SP - Brazil
[2] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072 - Australia
[3] CSIRO, Agr Flagship, Brisbane, Qld 4072 - Australia
[4] Univ Queensland, Ctr Anim Sci, Queensland Alliance Agr & Food Innovat, Brisbane, Qld 4067 - Australia
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BMC Genomics; v. 16, OCT 28 2015.
Citações Web of Science: 15
Resumo

Background: Asian buffaloes (Bubalus bubalis) have an important socio-economic role. The majority of the population is situated in developing countries. Due to the scarce resources in these countries, very few species-specific biotechnology tools exist and a lot of cattle-derived technologies are applied to buffaloes. However, the application of cattle genomic tools to buffaloes is not straightforward and, as results suggested, despite genome sequences similarity the genetic polymorphisms are different. Results: The first SNP chip genotyping platform designed specifically for buffaloes has recently become available. Herein, a genome-wide association study (GWAS) and gene network analysis carried out in buffaloes is presented. Target phenotypes were six milk production and four reproductive traits. GWAS identified SNP with significant associations and suggested candidate genes that were specific to each trait and also genes with pleiotropic effect, associated to multiple traits. Conclusions: Network predictions of interactions between these candidate genes may guide further molecular analyses in search of disruptive mutations, help select genes for functional experiments and evidence metabolism differences in comparison to cattle. The cattle SNP chip does not offer an optimal coverage of buffalo genome, thereafter the development of new buffalo-specific genetic technologies is warranted. An annotated reference genome would greatly facilitate genetic research, with potential impact to buffalo-based dairy production. (AU)

Processo FAPESP: 13/12851-5 - Expressão gênica para estudar a puberdade e a fertilidade em bovinos da raça Brahman
Beneficiário:Gregório Miguel Ferreira de Camargo
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 10/20887-1 - Aplicação de informações genômicas no melhoramento genético de bubalinos leiteiros
Beneficiário:Humberto Tonhati
Linha de fomento: Auxílio à Pesquisa - Regular