Redox Status and Neuro Inflammation Indexes in Cerebellum and Motor Cortex of Wistar Rats Supplemented with Natural Sources of Omega-3 Fatty Acids and Astaxanthin: Fish Oil, Krill Oil, and Algal Biomass

Autor(es)

Polotow, Tatiana G. ^[1] ; Poppe, Sandra C. ^[1] ; Vardaris, Cristina V. ^[1] ; Ganini, Douglas ^{[2, 1]} ; Guariroba, Maisa ^[1] ; Mattei, Rita ^[3] ; Hatanaka, Elaine ^[1] ; Martins, Maria F. ^{[4, 5]} ; Bondan, Eduardo F. ^{[4, 5]} ; Barros, Marcelo P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Cruzeiro Sul, Inst Phys Act & Sports Sci ICAFE, Postgrad Program Hlth Sci, BR-01506000 Sao Paulo, SP - Brazil

^[2] NIEHS, Free Rad Metab Grp, Lab Toxicol & Pharmacol, Res Triangle Pk, NC 27709 - USA

^[3] Fed Univ Sao Paulo UNIFESP, Dept Psychobiol, BR-04023062 Sao Paulo, SP - Brazil

^[4] Paulista Univ UNIP, Dept Environm & Expt Pathol, BR-04026002 Sao Paulo, SP - Brazil

^[5] Univ Cruzeiro Sul, Program Vet Med Biol Sci & Hlth CBS, BR-01506000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MARINE DRUGS; v. 13, n. 10, p. 6117-6137, OCT 2015.
• Citações Web of Science: 6

Resumo

Health authorities worldwide have consistently recommended the regular consumption of marine fishes and seafood to preserve memory, sustain cognitive functions, and prevent neurodegenerative processes in humans. Shrimp, crabs, lobster, and salmon are of particular interest in the human diet due to their substantial provision of omega-3 fatty acids (n-3/PUFAs) and the antioxidant carotenoid astaxanthin (ASTA). However, the optimal ratio between these nutraceuticals in natural sources is apparently the key factor for maximum protection against most neuro-motor disorders. Therefore, we aimed here to investigate the effects of a long-term supplementation with (n-3)/PUFAs-rich fish oil, ASTA-rich algal biomass, the combination of them, or krill oil (a natural combination of both nutrients) on baseline redox balance and neuro-inflammation indexes in cerebellum and motor cortex of Wistar rats. Significant changes in redox metabolism were only observed upon ASTA supplementation, which reinforce its antioxidant properties with a putative mitochondrial-centered action in rat brain. Krill oil imposed mild astrocyte activation in motor cortex of Wistar rats, although no redox or inflammatory index was concomitantly altered. In summary, there is no experimental evidence that krill oil, fish oil, oralgal biomass (minor variation), drastically change the baseline oxidative conditions or the neuro-inflammatory scenario in neuromotor-associated rat brain regions. (AU)

• Processo FAPESP: 09/12342-8 - Ação do carotenóide astaxantina na regulação do equilíbrio redox no músculo esquelético de ratos sob atividade física exaustiva (natação): projeto AstaSwim
• Beneficiário: Andréa Ramalho Mihaliuc
• Modalidade de apoio: Bolsas no Brasil - Mestrado