Redox Status and Neuro Inflammation Indexes in Cerebellum and Motor Cortex of Wistar Rats Supplemented with Natural Sources of Omega-3 Fatty Acids and Astaxanthin: Fish Oil, Krill Oil, and Algal Biomass

Author(s)

Polotow, Tatiana G. ^[1] ; Poppe, Sandra C. ^[1] ; Vardaris, Cristina V. ^[1] ; Ganini, Douglas ^{[2, 1]} ; Guariroba, Maisa ^[1] ; Mattei, Rita ^[3] ; Hatanaka, Elaine ^[1] ; Martins, Maria F. ^{[4, 5]} ; Bondan, Eduardo F. ^{[4, 5]} ; Barros, Marcelo P. ^[1]

Affiliation

^[1] Univ Cruzeiro Sul, Inst Phys Act & Sports Sci ICAFE, Postgrad Program Hlth Sci, BR-01506000 Sao Paulo, SP - Brazil

^[2] NIEHS, Free Rad Metab Grp, Lab Toxicol & Pharmacol, Res Triangle Pk, NC 27709 - USA

^[3] Fed Univ Sao Paulo UNIFESP, Dept Psychobiol, BR-04023062 Sao Paulo, SP - Brazil

^[4] Paulista Univ UNIP, Dept Environm & Expt Pathol, BR-04026002 Sao Paulo, SP - Brazil

^[5] Univ Cruzeiro Sul, Program Vet Med Biol Sci & Hlth CBS, BR-01506000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: MARINE DRUGS; v. 13, n. 10, p. 6117-6137, OCT 2015.
• Web of Science Citations: 6

Abstract

Health authorities worldwide have consistently recommended the regular consumption of marine fishes and seafood to preserve memory, sustain cognitive functions, and prevent neurodegenerative processes in humans. Shrimp, crabs, lobster, and salmon are of particular interest in the human diet due to their substantial provision of omega-3 fatty acids (n-3/PUFAs) and the antioxidant carotenoid astaxanthin (ASTA). However, the optimal ratio between these nutraceuticals in natural sources is apparently the key factor for maximum protection against most neuro-motor disorders. Therefore, we aimed here to investigate the effects of a long-term supplementation with (n-3)/PUFAs-rich fish oil, ASTA-rich algal biomass, the combination of them, or krill oil (a natural combination of both nutrients) on baseline redox balance and neuro-inflammation indexes in cerebellum and motor cortex of Wistar rats. Significant changes in redox metabolism were only observed upon ASTA supplementation, which reinforce its antioxidant properties with a putative mitochondrial-centered action in rat brain. Krill oil imposed mild astrocyte activation in motor cortex of Wistar rats, although no redox or inflammatory index was concomitantly altered. In summary, there is no experimental evidence that krill oil, fish oil, oralgal biomass (minor variation), drastically change the baseline oxidative conditions or the neuro-inflammatory scenario in neuromotor-associated rat brain regions. (AU)

• FAPESP's process: 09/12342-8 - The carotenoid astaxanthin as a redox switch in muscle tissues of rats submitted to exhaustive swimming exercise: the AstaSwim project
• Grantee: Andréa Ramalho Mihaliuc
• Support Opportunities: Scholarships in Brazil - Master