Different protocols of treadmill exercise induce distinct neuroplastic effects in rat brain motor areas

Autor(es)

Real, Caroline C. ^[1] ; Garcia, Priscila C. ^{[1, 2, 3]} ; Britto, Luiz R. G. ^[1] ; Pires, Raquel S. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Physiol & Biophys, Lab Cellular Neurobiol, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Cidade Sao Paulo, Masters Program Phys Therapy, BR-03071000 Sao Paulo, SP - Brazil

^[3] Univ Cidade Sao Paulo, Doctoral Program Phys Therapy, BR-03071000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1624, p. 188-198, OCT 22 2015.
• Citações Web of Science: 8

Resumo

A variety of exercise protocols have been used to promote experimental neuroplasticity. However, the plastic brain responses generated by several aspects of training (types, frequency, regimens, duration) remain undetermined. The aim of this study was to compare the plastic changes in the glutamatergic system and synaptic proteins in motor cortex, striatum and cerebellum promoted by two different treadmill exercise regimens. The present study analyzed by immunohistochemistry and Western blotting the expression of the subunits of AMPA receptors (GluA1 and GluA2/3) and synaptic proteins (synapsin I and synaptophysin) in adult male Wistar rat brains. The animals were divided into animals subjected to two different frequencies of aerobic exercise groups and sedentary animals. The exercise groups were: intermittent treadmill exercise (ITE) - animals that exercised 3 times a week (every other day) during four weeks, and continuous treadmill exercise (CTE) - animals that exercised every day during four weeks. Our results reveal that different protocols of treadmill exercise were able to promote distinct synaptic reorganization processes among the exercised groups. In general, the intermittent exercise regimen induced a higher expression of presynaptic proteins, whereas the continuous exercise regimen increased postsynaptic GluA1 and G1uA2/3 receptors. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/18161-5 - Respostas plásticas do sistema nervoso de ratos submetidos a diferentes modalidades de exercício físico
• Beneficiário: Raquel Simoni Pires
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/58716-3 - Efeitos do exercicio fisico em modelo de parkinson em ratos
• Beneficiário: Caroline Cristiano Real Gregório
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/25049-2 - Correlação de parâmetros celulares, moleculares, comportamentais e neurofuncionais na Doença de Parkinson com o exercício físico em modelo animal e em tecido humano postmortem
• Beneficiário: Caroline Cristiano Real Gregório
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado