Activity of neurons in the preoptic area and their participation in reproductive senescence: Preliminary findings

Autor(es)

Ferreira, Larissa Brazolotto ^{[1, 2]} ; de Nicola, Angela Cristina ^{[1, 2]} ; Anselmo-Franci, Janete Aparecida ^[3] ; Menegati Dornelles, Rita Cassia ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, SBFis UNESP, Programa Multicent Pos Grad Ciencias Fis, Aracatuba, SP - Brazil

^[2] UNESP Univ Estadual Paulista, Dept Basic Sci, Aracatuba Dent Sch, Lab Endocrine Physiol & Aging, Aracatuba, SP - Brazil

^[3] Univ Sao Paulo, Sch Dent Ribeirao Preto, Neuroendocrinol Lab, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Gerontology; v. 72, p. 157-161, DEC 2015.
• Citações Web of Science: 4

Resumo

Alterations in the hypothalamic-pituitary-gonadal axis in females determine the transition from regular to irregular reproductive cycles, with loss of fertility. Stimulation of noradrenergic neurons of the anteroventral periventricular neurons (AVPV) is essential for regular reproductive cycles. Therefore, we examined the activity of neurons of the AVPV and measure the noradrenaline (NE) of acyclic rats, in constant estrus, and compared it with that of cyclic rats in estrus. Female cyclic (4-5 months) and acyclic (17-18 months) rats were euthanized at 10,14, and 18 h in estrus. Brains were processed for immunoreactivity to antigens related to Fos (IRA) in AVPV, and the NE was determined by HPLC-ED. Plasma concentrations of LH, EH, E2 and P4 were determined. In the acyclic animals, plasma LH was higher but the FSH was lower. There was decreasing P4 at different times, while the E2 was constant and lower in acyclic rats. FRA-ir expression in AVPV neurons of acyclic rats as well as turnover of NE was higher when compared with cyclic group. The preliminary findings showed increased activity in AVPV neurons in aging contribute to changes in the temporal pattern of neuroendocrine signaling, compromising the accuracy of inhibitory and stimulatory effects, causing iiTegulaiity in the estrous cycle and determining reproductive senescence. (C) 2015 Elsevier Inc. All rights resented. (AU)

• Processo FAPESP: 12/14464-6 - Atividade dos neurônios noradrenérgicos do locus coeruleus e a liberação de GnRH em ratas Wistar acíclicas
• Beneficiário: Rita Cássia Menegati Dornelles
• Modalidade de apoio: Auxílio à Pesquisa - Regular