Gray matter volumes in patients with bipolar disorder and their first-degree relatives

Autor(es):Mostrar menos -

Nery, Fabiano G. ^{[1, 2]} ; Gigante, Alexandre Duarte ^[2] ; Amaral, Jose A. ^[2] ; Fernandes, Francy B. F. ^[2] ; Berutti, Mariangeles ^[2] ; Almeida, Karla M. ^[2] ; Carneiroc, Camila de Godoi ^[3] ; Souza Duran, Fabio Luis ^[3] ; Otaduy, Maria G. ^[4] ; Leite, Claudia Costa ^[4] ; Busatto, Geraldo ^[3] ; Lafer, Beny ^[2]

Afiliação do(s) autor(es)

^[1] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH - USA

^[2] Univ Sao Paulo, Dept Psychiat, Sch Med, Bipolar Disorder Program, BR-05403010 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo NAPNA USP, Lab Neuroimage Psychiat LIM 21, Res Appl Neurosci, Support Core, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Radiol & Oncol, Sch Med, Lab Neuroradiol LIM 44, BR-05403010 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PSYCHIATRY RESEARCH-NEUROIMAGING; v. 234, n. 2, p. 188-193, NOV 30 2015.
• Citações Web of Science: 5

Resumo

Bipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25 DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 05/56464-9 - Centro de Imagem em Neurociências da Faculdade de Medicina da Universidade de São Paulo
• Beneficiário: Giovanni Guido Cerri
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático