Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gray matter volumes in patients with bipolar disorder and their first-degree relatives

Full text
Author(s):
Show less -
Nery, Fabiano G. [1, 2] ; Gigante, Alexandre Duarte [2] ; Amaral, Jose A. [2] ; Fernandes, Francy B. F. [2] ; Berutti, Mariangeles [2] ; Almeida, Karla M. [2] ; Carneiroc, Camila de Godoi [3] ; Souza Duran, Fabio Luis [3] ; Otaduy, Maria G. [4] ; Leite, Claudia Costa [4] ; Busatto, Geraldo [3] ; Lafer, Beny [2]
Total Authors: 12
Affiliation:
[1] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH - USA
[2] Univ Sao Paulo, Dept Psychiat, Sch Med, Bipolar Disorder Program, BR-05403010 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo NAPNA USP, Lab Neuroimage Psychiat LIM 21, Res Appl Neurosci, Support Core, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Radiol & Oncol, Sch Med, Lab Neuroradiol LIM 44, BR-05403010 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PSYCHIATRY RESEARCH-NEUROIMAGING; v. 234, n. 2, p. 188-193, NOV 30 2015.
Web of Science Citations: 5
Abstract

Bipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25 DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School
Grantee:Giovanni Guido Cerri
Support Opportunities: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants