Spectroscopic analysis of aluminum chloride phthalocyanine in binary water/ethanol systems for the design of a new drug delivery system for photodynamic therapy cancer treatment

Autor(es)

Jayme, Cristiano Ceron ^[1] ; Calori, Italo Rodrigo ^[1] ; Tedesco, Antonio Claudio ^[1]

Afiliação do(s) autor(es)

^[1] SPECTRO, BR-14040901 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 153, p. 178-183, JAN 15 2016.
• Citações Web of Science: 21

Resumo

This study evaluated the behavior of aluminum chloride phthalocyanine in a binary water/ethanol mixture using electronic absorption spectroscopy and static and time-resolved fluorescence spectroscopy. The electronic absorption spectra, resonance light scattering and fluorescence quenching of aluminum chloride phthalocyanine in water/ethanol mixtures were studied at several concentrations. The electronic absorption spectra and fluorescence quenching changed significantly at approximately 50% water (v/v). Below 50% water, the dimerization constant values were negative (-2609.2 M-1 and -506.5 M-1 at 30% and 40% of water, respectively), indicating that the formation of aggregates under these conditions is not favored. However, at 50% water, the dimerization constant value was estimated to be 559.7 M-1, which indicates the presence of dimers. Above 60% water, the aggregation process was responsible for the balance between large complexes (such as trimers, tetramers or oligomers) formed in the medium under these conditions. The appearance of new absorption bands at 387 nm and 802 nm and their bathochromic shift relative to the monomer bands suggested that some I-type aggregates form. These results are relevant to understanding the behavior and use of aluminum chloride phthalocyanine in the design of new drug delivery systems for clinical application in photodynamic therapy as a new approach to treat skin cancer. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/50181-1 - Utilização de nanocarreadores contendo fármacos fotossensibilizantes e outros ativos aplicados à terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Antonio Claudio Tedesco
• Modalidade de apoio: Auxílio à Pesquisa - Temático